Author: sugaradmin

Introduction and Objective: The high relative free energy of phosphoenolpyruvate (PEP) positions pyruvate kinase (PK) as the driver of insulin secretion in beta-cells by increasing the ATP/ADP ratio and closing KATP channels. In this model, PK depletes ADP for mitochondrial OxPhos, leading to mitochondrial hyperpolarization and OxPhos inhibition. This study explores how PK-driven PEP hydrolysis […]

Introduction and Objective: Although small studies note that PCOS affects up to 1 out of 4 women with T1D, whether this applies to T1D more broadly is unknown. It is also unknown if PCOS confers cardiovascular disease (CVD) risk among youth with T1D, who are already at elevated risk. We examined whether PCOS was associated […]

Introduction and Objective: Current beta cell glucose sensing models require that substrate limited mitochondria can respond to glucose by increasing OxPhos ATP synthesis to close KATP channels (Rutter & Sweet, Diabetes 2024). A primary argument supporting their model is that glyceraldehyde (GA) can increase both respiration and insulin release. Here we test the axiom that […]

Introduction and Objective: Early identification of multi-system involvement in pre-diabetic and diabetic states remains challenging. This study investigated the timing and patterns of concurrent hepatic, bone, and metabolic derangements across different age groups and glycemic states.Methods: Cross-sectional analysis of 591 participants stratified by age (19-40, 41-60, >60 years) and glycemic status (non-diabetic, pre-diabetic, diabetic). Comprehensive […]

Introduction and Objective:Protein S-palmitoylation is a reversible modification involved in the β cell dysfunction that characterizes type 2 diabetes. Palmitate linked to cysteine is removed mostly through the activity of the depalmitoylase acyl-protein thioesterase 1 (APT1), an event important for intracellular trafficking and signaling. APT1 enzyme activity is decreased by hyperglycemia, and mice with islet-specific […]

Introduction and Objective: Although continuous glucose monitoring (CGM) is not indicated for inpatient use, the COVID-19 pandemic provided opportunities for hospital use beyond clinical trials. This analysis explored adult use from the Dexcom Hospital Registry, a database of real-world inpatient CGM use.Methods: This retrospective analysis included two US sites (ICU and non-ICU). Demographics, point-of-care (POC) […]

Introduction and Objective: The classification of maturity-onset diabetes of the young (MODY) pertains to monogenic forms of diabetes possessing an autosomal dominant mode of inheritance. The two most commonly seen subtypes are MODY2 and MODY3, caused by loss of function variants in the Glucokinase (GCK) and HNF1A genes, respectively. Our patient is an 18-year-old Caucasian […]

Introduction and Objective: We evaluated how early body roundness index (BRI), an anthropometric using waist circumference, affected rates of gestational diabetes (GDM) and hypertensive disorders of pregnancy (HDP).Methods: This is a secondary analysis of the Nulliparous Outcomes in Pregnancy: Monitoring Mothers to Be cohort, which followed nulliparous patients during pregnancy. First visit natural waist circumference […]

Introduction and Objective: Quinoline drugs were used to treat malaria from as early as 17th century. However, aside from their potent anti-malarial effects, hypoglycemia was associated with the use of quinine during the treatment for malaria, which was attributed to the drug directly evoking insulin secretion through KATP channel inhibition. In this study, we aim […]

Introduction and Objective: Understanding physicians’ perceptions of Patient Support Programs (PSPs) is critical for optimizing their impact on patient engagement, adherence, and outcomes in metabolic care. PSPs aim to enhance cardio-metabolic care through features like personalized dietary guidance, self-management tools, affordability, and accessibility. This mapping exercise evaluates physicians’ perspectives to refine PSP design and implementation, […]