Author: sugaradmin

Introduction and Objective: Decreased insulin sensitivity (resistance) is associated with higher T2D risk. Identifying reliable surrogate indexes that are convenient and that use standard clinical assays might improve prevention of T2D. We compared the ability of 15 indexes to predict future T2D in Southwest US American Indians.Methods: We calculated indexes obtained from oral glucose tolerance […]

Introduction and Objective: The large-conductance Ca2+-activated K+ (BK) channel is critical in regulation coronary circulation, with its expression tightly regulated by Sorbin and SH3 domain-containing protein 2 (Sorbs2). Sorbs2 expression is downregulated in coronary arteries, contributing to BK channelopathy and vasculopathy in diabetic animals. However, the role of Sorbs2 in BK channel function in human […]

In this special episode on Treatment of Hypercortisolism in Uncontrolled Diabetes our host, Dr. Neil Skolnik, will discuss new evidence showing the surprising prevalence of Hypercortisolism in people with uncontrolled Type 2 Diabetes, and the effect of treatment.  This special episode is supported by an independent educational grant from Corcept. Presented by: Neil Skolnik, M.D., […]

Introduction and Objective: The proliferation of preadipocytes favors global metabolic homeostasis. Our study aims to explore the role of mitochondrial protein Optic atrophy 1 (OPA1) in preadipocytes in regulating metabolic disorders and elucidate underlying mechanisms.Methods: We generate preadipocyte-specific KO mice (OPA1PKO) with OPA1flox/flox and Pdgfrα-Cre mice and overexpression mice (OPA1OE) by AAV-DIO injection in Pdgfrα-Cre […]

Introduction and Objective: Diabetic peripheral atherosclerosis is an important marker of macrovascular complications in diabetes. Changes in the thickness of carotid atherosclerotic plaques can indicate early macrovascular alterations in diabetes. The aim of this study is to observe the impact of PCSK9 inhibitors (PCSK9i) on changes in carotid plaque thickness in patients with diabetes without […]

Introduction and Objective: In individuals with T1D, increased change in CGM (ΔG) is common during physical activity (PA) due to 3 main factors: impaired endogenous glucose production (ΔGegp), increased insulin-dependent glucose utilization (ΔGid), and increased insulin-independent glucose clearance (ΔGii) by skeletal muscles. To understand how the factors affect ΔG during PA, we identify a data-driven […]

Introduction and Objective: Imeglimin, a drug for type 2 diabetes, reportedly promotes β-cell proliferation and β-cell survival; however, the underlying molecular mechanism remains unclear.Methods: We investigated The metabolites in islets after imeglimin treatment via LC-MS.Results: Treatment with imeglimin for one hour significantly altered the levels of 17 metabolites at 5.6 mM glucose and 11 metabolites […]

Introduction and Objective: Type 2 diabetes (T2D), affecting 537 million individuals globally, disproportionately impacts Latin American populations, who experience higher rates of diabetic complications. Despite large-scale genomic studies identifying T2D-associated variants enriched in this population, many lie in non-coding regions, complicating the identification of causal genes. Existing genomics resources like GTEx were developed using data […]

Introduction and Objective: Increasing evidence suggests that stress pathways intrinsic to the β cell contribute to their destruction during type 1 diabetes (T1D) development. Our group has previously shown that loss of sarco-endoplasmic reticulum calcium (Ca2+) pump 2 (SERCA2) exacerbates high-fat diet-induced diabetes in murine models. Here, we assessed whether SERCA2 haploinsufficiency exacerbates loss of […]

Introduction and Objective: Chronic disease behavioral interventions have become widespread across healthcare sectors. While success of these interventions is largely dependent on their implementation, there is an absence of train-the-trainer (TTT) protocols and evaluations to serve as frameworks for behavioral interventions. Therefore, the objective of this study was to develop and evaluate the effectiveness of […]