Author: sugaradmin

Introduction and Objective: Type 1 diabetes mellitus (T1DM) is associated with increased risks of adverse pregnancy outcomes. While Continuous Glucose Monitoring Systems (CGMS) improve glycemic monitoring, self-monitoring of blood glucose (SMBG) remains the primary method for most pregnant women due to accessibility and cost barriers. This study aimed to evaluate the association between time-in-range (TIR) […]

Introduction and Objective: Type 2 diabetes (T2D) is a major public health challenge in the U.S., accounting for 90-95% of all diabetes cases. Individuals with A1C levels above 8% face increased risks of complications; however, diabetes self-management education (DSME) can effectively reduce A1C levels. Proactive DSME is essential for managing these patients. This retrospective analysis […]

Introduction and Objective: Adipocytes expand remarkably in size during positive energy balance, closely linked to metabolic health. However, the molecular mechanisms underlying adipocyte hypertrophy remain poorly understood. This study aims to identify transcriptional drivers of adipocyte hypertrophy in obesity.Methods: Bioinformatics analyses of ChIP-seq on adipocytes under varying nutrient availability identify super-enhancers and their associated transcriptional […]

Introduction and Objective: Research on using electronic platforms to adjust diets for type 2 diabetes (T2D) patients with CGM data is scarce. This study aimed to evaluate the effectiveness of personalized dietary advice based on CGM data delivered through a digital platform for newly diagnosed T2D patients, focusing on glycemic control and management adherence.Methods: A […]

Introduction and Objective: To evaluate whether higher engagement with a ​​digital diabetes self-management and education support (DSMES) program + continuous glucose monitoring (CGM) integrated solution is associated with better clinical outcomes through a secondary analysis of a randomized controlled trial.Methods: Participants with type 2 diabetes and HbA1c ≥ 8% not using mealtime bolus insulin (26-83 […]

Introduction and Objective: Type 2 diabetes (T2D) prevalence among U.S. Hispanics exceeds the national average, driven by socioeconomic challenges, genetic predispositions, and limited healthcare access. Variations across subgroups suggest cultural and immigration-related factors may play a role. This study evaluates the association of these factors with T2D and prediabetes among rural Hispanic/Latino adults.Methods: This cross-sectional […]

Introduction and Objective: Chronic Type 2 Diabetes Mellitus (T2DM) is a global health concern, disproportionately affecting African Americans (AA) in the USA. This study investigates gene expression in Amyloid Processing Pathways (APP) and cholesterol biosynthesis-related genes and identifies the key pathways and their roles in linking T2DM to Alzheimer’s Disease (AD) risk in AA.Methods: In […]

Introduction and Objective: Type 2 diabetes mellitus (T2DM) is a major global health concern, significantly increasing the risk of dyslipidemia, which contributes to macrovascular complications. This study aims to explore the correlation between HbA1c levels and lipid parameters in elderly T2DM patients, emphasizing the implications for managing dyslipidemia in this population.Methods: This retrospective cross-sectional study […]

Introduction and Objective: The widely prevalent C variant of SNP rs13266634, encoding an amino acid exchange in the ß-cell specific zinc (Zn) transporter ZnT8, is associated with type 2 diabetes. The relationship between Zn status, ZnT8 genotype at rs13266634, and ß-cell function is underexplored.Methods: Zn concentration in urine samples -uZn, a proxy for Zn status- […]