Sugar is Not Your Friend

Introduction and Objective: Diabetes mellitus is associated with pronounced hepatic oxidative stress caused by excessive reactive oxygen species production, impaired antioxidant defenses, and activation of stress-responsive signaling pathways. Building on evidence of the antidiabetic potential of Hypericum perforatum L. aerial parts (Hyperici herba, HH) and H. perforatum hairy root (HR) extracts, this study aimed to […]

Introduction and Objective: Efsubaglutide alfa (Suba) is a novel GLP-1RA. ENLIGHT is a seamless Phase 2b/3 program; the Phase 2b stage evaluated Suba regimens to inform dose selection for the subsequent Phase 3 study.Methods: This double-blind, placebo (PBO)-controlled trial (NCT06921486) randomized participants to Suba 5, 10, or 20 mg once weekly (QW), 20 mg once […]