Multiple Mechanisms Contribute to Robust Type 1 Diabetes Protection in Nfkbid – Overexpressing NOD Mice
We previously reported that transgenic overexpression of Nfkbid in NOD mice led to robust type 1 diabetes protection associated with enhanced negative selection of autoreactive T cells and expansion of regulatory T cells (Tregs) with increased suppressive capacity. The goal of this study was to further identify cellular and molecular mechanisms underlying strong protection from […]
