Sugar is Not Your Friend

Introduction and Objective: This secondary analysis of the GO MOMs cohort evaluated associations of first trimester maternal BMI, CGM, OGTT, HbA1c and metabolic measures with newborn adiposity.Methods: At 9 US centers gravidas with singletons and no pre-existing diabetes underwent 75g OGTT, HbA1c, CGM and fasting lipid measures (free fatty acids-FFA; triglycerides-TG) at 10-14 weeks’ gestation. […]

Introduction and Objective: Diabetic vasculopathy is a major complication of type 2 diabetes (T2DM), and endothelial senescence is a key driver of endothelial dysfunction and impaired angiogenesis. We tested whether ANGPTL8 promotes endothelial senescence in T2DM and explored the underlying mechanism.Methods: HUVECs were treated with recombinant ANGPTL8. qPCR assessed P21, P53, senescence-associated secretory phenotype genes […]

Introduction and Objective: In NOD mice, impaired T cell development and negative selection are implicated in disease development. However, in T1D patients, it remains unknown whether abnormalities in thymic selection contribute to disease development. Our knowledge of human T Cell Receptor (TCR) repertoire formation is limited by lack of access to human thymi. Thus, humanized […]