Sugar is Not Your Friend

Optimal function of beige adipocytes is essential for energy balance and metabolic homeostasis. We previously identified that cholinergic receptor nicotinic α2 subunit (CHRNA2) mediates a beige fat selective signaling in mice and humans. Here, we investigate the molecular composition of CHRNA2-containing nicotinic acetylcholine receptors (nAChRs) in beige adipocytes and its impact on whole-body metabolism. Expression […]

Central administration of fibroblast growth factor-19 (FGF19) has been shown to reduce body weight in obese mice, but the underlying mechanisms remain largely unknown. Here, we show that ribosomal S6 kinase 4 (Rsk4) is required for FGF19 to counteract obesity. Rsk4 is predominantly expressed in hypothalamic neurons. While loss of Rsk4 has negligible effects on […]

Thioredoxin-interacting protein (TXNIP) is regarded as a potential therapeutic target in type 2 diabetes. Hyperglycemia can upregulate the expression of TXNIP in various cell types, thereby inducing oxidative stress. However, the regulatory mechanisms by which this protein modulates vascular function in the aorta remain incompletely elucidated. This study aimed to investigate the response of TXNIP […]