Sugar is Not Your Friend

Introduction and Objective: Type I (IFNα) and Type II (IFNγ) interferons have been shown to play a critical role in T1D pathogenesis. Studies on pancreatic biopsies from individuals with recent-onset T1D suggest an upregulation of IFN-stimulated gene signatures. However, their impact on the β-cell epitranscriptome and translatome remains untested.Methods: Human islets from 12 cadaveric donors […]

Introduction and Objective: T2D is a heterogeneous disease involving defects in multiple metabolic processes, which could be assessed by partitioned pathway-specific polygenic scores (pPS) developed from clustering T2D GWAS lead variants based on associations with related cardiometabolic traits. Here, we demonstrate the use of T2D pPS to identify T2D patient subgroups with distinct clinical features […]