Introduction and Objective: We evaluated how early body roundness index (BRI), an anthropometric using waist circumference, affected rates of gestational diabetes (GDM) and hypertensive disorders of pregnancy (HDP).Methods: This is a secondary analysis of the Nulliparous Outcomes in Pregnancy: Monitoring Mothers to Be cohort, which followed nulliparous patients during pregnancy. First visit natural waist circumference and height were used to calculate BRI via 364.2 − 365.5 × √(1 − [WC / 2π]2 / [0.5 × ht]2. Characteristics and outcomes were compared with BRI quartiles. Area under the curve (AUC) was compared between BRI and BMI. Multivariable logistic regression estimated the association of BRI >50th%ile with GDM and HDP with stratified analyses by BMI category.Results: Analysis included 9,675 individuals. Increasing BRI quartile was associated with GDM (1.8 vs 2.3 vs 4.6 vs 8.2%, p<0.001) and HDP (16.7 vs 18.9 vs 23.4 vs 34.1%, p<0.001). There were minor differences in AUC for BRI vs BMI for GDM (0.69 ±0.01 vs 0.66 ±0.01, p=0.001) and HDP (0.60 ±0.01 vs 0.62 ± 0.1, p<0.001). BRI >50th%ile was associated with GDM but not HDP in normal and overweight BMI groups (Table).Conclusion: Early elevated BRI is associated with GDM but may not offer advantage clinically over BMI. Studies are needed to determine if BRI can predict GDM risk in pregnant individuals with normal and overweight BMIs.
K.J. Pape: None. T. Bynarowicz: None. D.M. Haas: None. L.D. Yee: None. R. Silver: None. J. Chung: None. L.D. Levine: None. C.M. Scifres: Consultant; Otsuka/Visterra Pharmaceuticals.
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