Month: September 2026

Both of Herman’s grandfathers were engineers. One began as a custodian for the Glenn L. Martin Company before moving into engineering and then starting his own businesses. The other worked alongside the RCA Corporation to develop radar. “Technology was moving away from vacuum tube–based electronic systems,” Herman says, “so he got upfront practical knowledge of […]

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We read with great interest the study by Meier et al. (1), which shows that long-term weight loss after lifestyle intervention does not confer uniform metabolic benefit across type 2 diabetes risk clusters. Among participants who maintained ≥3% weight loss at ∼9 years, cluster 5 had worsening fasting glycemia, the greatest decline in adjusted insulin secretion, […]

The article by Raineri et al. (1), published recently in Diabetes, has a number of fundamental miscalculations that render impossible the extraction of any conclusions on total and memory regulatory T cells (Tregs). Specifically, the manuscript presents as total Tregs all CD3+CD4+CD25highCD127low/− cells and as memory Tregs all Tregs that are CD45RO+. This is simply not […]

We read with great interest the letter by Chen et al. (1) in this issue of Diabetes and appreciated their insightful comments on our recent work (2). We are pleased that the authors recognized the clinical relevance of our findings, regarding the diverse interplay between insulin resistance and endogenous insulin secretion in individuals suffering from latent […]

We thank Petsiou et al. (1), Gootjes et al. (2), and Bruzzaniti et al. (3), in this issue of Diabetes, for their interest in our work (4) and for the opportunity to further discuss the interpretation of phenotypically defined regulatory T cell (Treg) populations in early type 1 diabetes (T1D). Although the three commentaries emphasize different aspects of […]