Weight maintenance is a challenging topic for both clinicians and patients. In this special episode, Neil Skolnik is joined by Jamie Almondoz, MD, who discusses the toxic narratives that have historically been part of the weight loss conversation, and the latest strategies for maintaining a healthy weight after the initial loss. This special episode is […]
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Share on PinterestResults from two clinical trials show that a common rheumatoid arthritis drug, upadacitinib, supported hair regrowth in alopecia. Viktoriya Skorikova/Moment/Getty Images Researchers report that the drug upadacitinib, used to treat rheumatoid arthritis, effectively treated the hair loss condition alopecia areata in two clinical trials. The medication, sold under the brand name Rinvoq, is […]
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As confusion and misunderstanding about perimenopause persist, learn how to recognize and manage symptoms of this life transition. Share on PinterestNot everyone experiences perimenopause in the same way. The timing, severity, and symptomology may differ greatly from one person to the next. Olga Pankova/Moment/Getty Images Perimenopause has only recently entered the cultural conversation despite being […]
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Share on PinterestYoung men are “T-maxxing” their testosterone levels on social media to optimize their bodies and mood. aire images/Moment/Getty Images “Testosterone-maxxing” or “T-maxxing” is a social media trend that promotes testosterone for improved strength, appearance, and confidence in young men. While medically appropriate in some cases, boosting testosterone with unprescribed hormones can suppress natural […]
Read MoreOptimal function of beige adipocytes is essential for energy balance and metabolic homeostasis. We previously identified that cholinergic receptor nicotinic α2 subunit (CHRNA2) mediates a beige fat selective signaling in mice and humans. Here, we investigate the molecular composition of CHRNA2-containing nicotinic acetylcholine receptors (nAChRs) in beige adipocytes and its impact on whole-body metabolism. Expression […]
Read MoreCentral administration of fibroblast growth factor-19 (FGF19) has been shown to reduce body weight in obese mice, but the underlying mechanisms remain largely unknown. Here, we show that ribosomal S6 kinase 4 (Rsk4) is required for FGF19 to counteract obesity. Rsk4 is predominantly expressed in hypothalamic neurons. While loss of Rsk4 has negligible effects on […]
Read MoreThioredoxin-interacting protein (TXNIP) is regarded as a potential therapeutic target in type 2 diabetes. Hyperglycemia can upregulate the expression of TXNIP in various cell types, thereby inducing oxidative stress. However, the regulatory mechanisms by which this protein modulates vascular function in the aorta remain incompletely elucidated. This study aimed to investigate the response of TXNIP […]
Read MoreThe progressive decline of functional β-cell mass is a hallmark of type 2 diabetes (T2D), yet no current therapies effectively halt this process. While chronic inflammation and metabolic stress contribute to β-cell dysfunction, the key signals integrating these pathways remain elusive. Circulating adenosine deaminase (ADA) elevation in people with diabetes is often viewed as a […]
Read MoreImpaired cognitive function caused by insulin-induced hypoglycemia is a complication of type 1 diabetes mellitus (T1DM) for which no protective strategies are currently available. In this first-in-human mechanistic study using magnetic resonance spectroscopy, the direct contribution of the infused ketone β-hydroxybutyrate (BHB) to brain metabolism during clamped hypoglycemia was greater in participants with T1DM than […]
Read MoreObesity is a major contributor to cardiometabolic disease, and pharmacological therapies, such as semaglutide, are increasingly used to induce weight loss. However, the commonly used diet-induced obesity model in C57BL/6J mice is limited by relative resistance to weight gain in females, complicating the study of sex-specific effects. Here, we used leptin-deficient ob/ob mice, which develop […]
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