NKX2.2 is a transcription factor that regulates pancreatic islet β-cell identity and function; however, cofactor proteins that modulate the functional activity of NKX2.2 in β-cells are relatively unexplored. An unbiased proteomics screen identified chromodomain helicase DNA-binding protein 4 (CHD4) as an NKX2.2 interacting partner. CHD4 is a nucleosome remodeler that directs the appropriate differentiation, maturation […]
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The Glucagonotropic Effect of GIP Is Negated During Insulin-Induced Hypoglycemia in Type 1 Diabetes: A Randomized, Placebo-Controlled, Crossover Study
Glucose-dependent insulinotropic polypeptide (GIP[1–42]) increases glucagon levels in the presence of normal-to-low plasma glucose concentrations in individuals with type 1 diabetes (T1D), suggesting its potential use as a safeguard against hypoglycemia. We investigated the dose-dependent effects of exogenous full-length GIP[1–42] and its truncated variant GIP[1–30]NH2 on glucagon concentrations during insulin-induced hypoglycemia in individuals with T1D. […]
Read MoreEstrogen Mediates Capacity for Hyperplastic Adipose Expansion and Preserves Adipose Progenitor Cell Availability in Subcutaneous Depots of Female Mice
Female protection against cardiometabolic disease wanes after menopause, concomitant with a transition toward the male-like pattern of visceral adiposity. Since recruitment of adipose progenitor cells (APCs) to support adipose expansion is depot-specific and thought to maintain metabolic homeostasis, sex differences in the capacity for APC differentiation were explored as a mechanism underlying female cardiometabolic protection. […]
Read MoreHHS to Update Testosterone Therapy Warning Labels
Share on PinterestHHS announced it would request updates to the warning labels for testosterone replacement therapy products. Malorny/Getty Images The Department of Health and Human Services (HHS) has proposed key changes to the labeling of testosterone replacement therapy (TRT) products. The proposed changes could expand access to TRT for men with idiopathic and age-related hypogonadism. […]
Read MoreHMGA1 Lactylation–Mediated Regulation of the SP1/VEGFA Axis in Pathological Angiogenesis Under Diabetic Retinopathy
Diabetic retinopathy (DR), a major complication of diabetes that causes blindness, is characterized by hyperglycemia-induced vascular dysfunction of incompletely defined mechanisms. Our study demonstrated glycolytic pathway activation in a DR rat model, which led to lactate accumulation and elevated pan lysine lactylation. Reduced lactate levels ameliorate vascular dysfunction. Global lactylome analysis of rat retinal tissues […]
Read MoreDistinct Interplay Between β-Cell Function and Insulin Resistance in Latent Autoimmune Diabetes in Adults Versus Type 2 Diabetes
We conducted a cross-sectional study to explore the interplay between β-cell function and peripheral insulin resistance in latent autoimmune diabetes in adults (LADA) compared with type 2 diabetes. Thirty-one people with LADA were matched for sex, BMI, and disease duration with 31 people with type 2 diabetes. Insulin resistance was estimated using established surrogate indexes, […]
Read MoreOff-Duty EMT Saves Knicks Fan With Narcan as FDA Widens Access to Drug
Share on PinterestNEW YORK, NEW YORK – JUNE 18: Fans cheer for the New York Knicks as a float with Karl-Anthony Towns and teammates pass by during the New York Knicks Championship ticker tape parade and victory rally celebrating winning the 2026 NBA Finals on June 18, 2026 in New York City. The New York […]
Read MoreGlycemic Improvement and Active Charcot Neuroarthropathy: Osteocalcin as a Candidate Biomarker of Transient Skeletal Vulnerability
Active Charcot neuroarthropathy (CN) remains difficult to predict. This hypothesis-generating article proposes a deliberately restricted, testable model in which a clinically meaningful fall in HbA1c may temporally coincide with active CN in a subset of people with diabetes, established neuropathy, and a vulnerable foot. The signal is based on a sequence of observations—an initial case […]
Read MoreHow Discovering a Neck Lump Led to 2 Rare Tumors and a 24-Hour Surgery
Share on PinterestJayme Cohen Lynde’s rare tumor diagnosis led to a major surgery and a long recovery. Now, she is a thriving mom of two daughters. Image Credit: Photos by Jayme Cohen Lynde/Collage by Andrew Nguyen A lump in Jayme Cohen Lynde’s neck led to a carotid body tumor diagnosis and a second rare tumor […]
Read MoreProtection Against Periodontitis by Improving Mitochondrial Function in Diabetes
Diabetes is a major risk factor for severe periodontitis. This is partly due to impaired wound healing associated with concomitant failure to resolve inflammation and chronic infection. Studies from the Joslin Medalist Cohort, people with >50 years of type 1 diabetes, have reported that protective factors exist to delay the onset of severe retinopathy, nephropathy, […]
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