With over 200,000 hospital admissions each year from diabetic ketoacidosis, new continuous ketone monitoring systems can address a critical care gap. In the second part of our special series, Neil Skolnik explores the value of this new technology and delves into specific case studies. This special episode is sponsored with support from Abbott. Presented by: […]
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There are multiple options now for slowing the progression of chronic kidney disease. In part 5 of our special series, host Dr. Neil Skolnik takes a case-based approach to explore treatment options for CKD. This special episode is sponsored with support from Bayer. Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney […]
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Welcome to the latest episode (November 2026) of DOC Updates, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month on DOC Updates: Oser, et al. Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes. New England Journal of Medicine. October 2026; doi.org/10.1056/NEJMoa2608571 […]
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We are entering an era of choice in terms of diabetes and obesity therapies. Choice is good, but having a keen understanding of each medication is crucial to avoid being overwhelmed. In this special episode of DOC Updates, host Dr. Neil Skolnik explores the latest amylin-based therapies. This special episode is sponsored with support from […]
Read MoreIntrapancreatic fat deposition is a well-established biomarker for type 2 diabetes mellitus (T2DM), but little is known about the role of pancreatic perivascular adipose tissue (PVAT), fat surrounding blood vessels supplying the pancreas. The objectives of this study were to develop a fully automated pipeline to derive imaging biomarkers of pancreatic PVAT from abdominal computed […]
Read MoreWe investigated whether sustained high-frequency feeding (six meals per day) increases type 2 diabetes mellitus (T2DM) incidence and alters diurnal metabolic patterns in male KKAy mice. Mice were randomly assigned to three or six isocaloric meals per day for 60 days. Metabolic phenotyping, tissue glycogen assays, multitissue circadian clock gene analysis, and exploratory correlation analyses […]
Read MorePrimary cilia are sensory cellular appendages that regulate diverse developmental and homeostatic processes, including energy homeostasis. In animal models and humans, their dysfunction can lead to hyperphagia and obesity. ARL13B is a regulatory GTPase enriched in cilia. We engineered an Arl13b mouse allele, Arl13bV358A, that disrupts ARL13B from localizing to primary cilia. Homozygous Arl13bV358A/V358A mice […]
Read MoreWe analyzed baseline serum samples from 41 individuals newly diagnosed with type 1 diabetes (T1D) enrolled in the Autoimmunity-blocking Antibody for Tolerance (AbATE) trial (NCT00129259) to identify metabolic predictors of teplizumab response. Responders to teplizumab were defined as individuals who exhibited <45% decline in baseline C-peptide levels at 2 years after start of treatment. We […]
Read MoreLocalized subcellular muscle lipid accumulation associates with insulin resistance, but independent effects of weight loss or exercise training are unknown. Forty-six men and women with obesity completed 12-week weight loss only, endurance exercise training only without weight loss, or delayed control interventions. Following weight loss, body weight decreased 10% along with a 42% increase in […]
Read MoreHepatocyte growth factor (HGF)/c-Met signaling is a well-established pathway through which external signals regulate β-cell resilience and function. Yet the endogenous source of HGF in the islets and its physiological role in this context remain unclear. Here, we combined human islet single-cell transcriptomics with mouse pancreatic-cell profiling to show that pericytes, rather than endothelial cells, […]
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