488-P: Correlation of HbA1c Levels with Lipid Profile in Type 2 Diabetes Mellitus Patients—A Retrospective Cross-Sectional Study



Introduction and Objective: Type 2 diabetes mellitus (T2DM) is a major global health concern, significantly increasing the risk of dyslipidemia, which contributes to macrovascular complications. This study aims to explore the correlation between HbA1c levels and lipid parameters in elderly T2DM patients, emphasizing the implications for managing dyslipidemia in this population.Methods: This retrospective cross-sectional study analyzed clinical data from 300 T2DM patients (60% male) who visited Parul Sevashram Hospital, Vadodara, Gujarat, between January and April 2025. Sociodemographic information and laboratory values, including HbA1c and lipid profiles, were extracted from hospital records. Dyslipidemia was defined using standard lipid profile thresholds. Statistical analysis was performed to evaluate correlations between HbA1c levels and lipid parameters, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and triglycerides (TGs).Results: The study population had a mean age of 62 years, with 43% aged between 55 and 64 years. Dyslipidemia was prevalent, with 60% of patients having elevated LDL-c, 40% with low HDL-c, and 35% each with elevated triglycerides and total cholesterol levels. A statistically significant positive correlation was observed between HbA1c and TC (p<0.01) as well as TGs (p<0.01), indicating that poor glycemic control is closely associated with dyslipidemia in T2DM patients.Conclusion: This study highlights a significant association between HbA1c levels and dyslipidemia, particularly with cholesterol and triglyceride levels, in T2DM patients. These findings underscore the need for integrated management strategies targeting both glycemic control and lipid abnormalities to mitigate cardiovascular and microvascular risks in this population. Further research is warranted to establish causality and optimize therapeutic interventions.

Disclosure

V.M. Rathod: None. D. Raval: None. P. Thammireddy: None. M. Subhan: None. A. Bhattacharya: None.



Source link