Author: sugaradmin

Introduction and Objective: Heart failure (HF) is common in diabetes and may be asymptomatic in earlier stages. NT-proBNP and BNP [collectively natriuretic peptides (NP)] detect early HF in asymptomatic individuals who could benefit from disease-modifying therapies. We examined the prognostic value of NP levels in people with type 1 (T1D) or type 2 (T2D) diabetes […]

Introduction and Objective: To investigate how β-cell glucose sensitivity, insulin clearance, and insulin sensitivity interact to determine glucose tolerance.Methods: We analyzed data from 54 healthy individuals (age 44 years IQR 27-56, 63% females, BMI 24.5 kg/m² IQR 21.9-28.7, HbA1c 33.26 mmol/mol IQR 32.13-35.51) undergoing a 3-hour OGTT. β-cell glucose sensitivity, insulin clearance, and insulin sensitivity […]

Introduction and Objective: Spasmolytic polypeptide expressing metaplasia (SPEM), which is considered as origin of gastric cancer, is associated with obesity. However, the fundamental determinants and mechanisms underlying obesity-associated SPEM remain poorly understood.Methods: Our metabolomics study analyzed 42 obese patients to assess the association between n-6 polyunsaturated fatty acids (PUFAs) and SPEM. Gastric organoids and mouse […]

Introduction and Objective: Insulin secretion in nondiabetic individuals is inversely related to the prevailing level of insulin sensitivity. The aim of the present study was to characterize insulin secretion caused by GLP-1 RA in non diabetic individualsMethods: 251 subjects free of T2DM received a 2-step hyperglycemic clamp (+125 mg/dl, and +400 mg/dl) followed by intravenous […]

Introduction and Objective: Obesity and T2D remain major health concerns worldwide. We have recently described a centrally acting aminosterol, ENT-03, that induces weight loss in obese and lean rodents. ENT-03 is a synthetic version of the mammalian natural product, which is in Phase 1 clinical trials for treatment of type 2 diabetes and obesity. In […]

Introduction and Objective: Rates of nutrient delivery to the small intestine is one of major determinants of prandial glucose homeostasis. Rapid and accentuated rise in prandial blood glucose accompanying hyperinsulinemia is the hallmark of gastric bypass surgery (GB). However, it is unclear to what extent the rate of enteral nutrient flux due to rerouted gut […]

Introduction and Objective: Mesenchymal Stem Cells’ (MSCs) immunemodulatory & anti-inflammatory actions make them effective Regenerative Medicine tools for Diabetes and its complications. MSCs can be used allogeneically, but patients prefer to use their own cells. Intrinsic MSCs from T1 & T2DM subjects exhibit dysfunctions that may contribute to the comorbidities and inflammation associated with DM. […]

Introduction and Objective: Type 1 Diabetes Mellitus (T1DM) poses a significant health challenge for youth globally. This study examines mortality trends in ages 15-39 from 1990 to 2021.Methods: GBD data were analyzed to assess the mortality rates per 100,000 of T1DM in individuals aged 15-39. The Estimated Annual Percentage Change (EAPC) was used to evaluate […]

Introduction and Objective: Fructosamine reflects glycemic control over 2-3 weeks via albumin turnover, offering a short-term alternative to HbA1c. Its perioperative use has increased, but no consensus exists on the best formula for estimating average glucose from fructosamine. This study assessed the correlation between CGM and fructosamine and identified the best-aligned formula preoperatively.Methods: This retrospective […]

Introduction and Objective: Various health-related social needs (HRSNs) are associated with diabetes outcomes, but little is known about their joint effects. We evaluated the association of the number of unmet HRSNs with hemoglobin A1c (HbA1c), acute diabetes complications, and healthcare utilization among youth and young adults (YYA) with youth-onset type 1 diabetes (T1D), and whether […]