Introduction and Objective: Fee-for-service healthcare makes it difficult for people with T1D to access the care, education, and support that they need. Blue Circle Health (BCH) is a program that closes this gap. BCH is delivered remotely, is 6 months long, and includes coordinated services of endocrinology, peer support, diabetes counseling, case management, insurance navigation, […]
Read MoreAuthor: sugaradmin
1033-P: Interstitial vs. Arterialized-Venous Glucose Under Experimental Hypoglycemia in Type 2 Diabetes
Introduction and Objective: Interstitial glucose concentrations are gaining clinical relevance with advances in CGM, as they more closely reflect glucopenia in cerebral and cardiac tissues. We therefore studied interstitial vs. arterialized-venous (AV) glucose differences during hypoglycemia.Methods: Participants with T2D underwent hyperinsulinemic-hypoglycemic clamps (YSI glucose 2.5 mmol/L [45 mg/dL] for 60 minutes). Interstitial glucose (Dexcom G6, […]
Read More665-P: Association between Housing Insecurity and Hemoglobin A1c among Adults with Type 2 Diabetes—A Cross-Sectional Analysis of the All of Us Research Program
Introduction and Objective: Housing insecurity is an upstream social determinant of the health factors associated with poor health outcomes. Among adults with diabetes, there is little evidence of an association between housing insecurity and glycemic control. Therefore, a secondary data analysis was conducted to assess the association between housing insecurity and hemoglobin A1C (HbA1C) among […]
Read More852-P: Factors Associated with the Use of Adjunct-to-Insulin Glucose-Lowering Agents in Patients with Type 1 Diabetes Mellitus
Introduction and Objective: Adjunct-to-insulin metformin, Glucagon-Like Peptide-1 receptor agonists (GLP1-RA), and Sodium Glucose Co-transporter 2 inhibitors (SGLT2i), mostly off-label, are used by people with type 1 diabetes (PwT1D) to address the challenges of glucose control and other outcomes. We investigated the socio-demographic and disease-related characteristics associated with their use.Methods: Cross-sectional comparison of self-reported demographic and […]
Read More664-P: Identifying Diabetes Distress across Adult Age Groups—Insights from the ReDUCe Study
Introduction and Objective: Diabetes distress, the emotional and behavioral challenges of living with type 1 diabetes (T1D), is common over the lifespan and can lead to adverse medical and psychological outcomes. Interventions that incorporate stakeholder input on diabetes distress across the lifespan remain limited. The ReDUCe Study aims to reduce diabetes distress in adults with […]
Read More28-OR: GLP1R R131Q is a Gs-Biased Gain-of-Function Variant Associated with Preservation of β-Cell Function
Introduction and Objective:GLP1R R131Q (rs3765467) has been reported as a type 2 diabetes protective variant in genome-wide association studies and glucagon-like peptide-1 receptor (GLP1R) activation has been shown to have various β cell protective effects. We hypothesized that the variant induces a gain-of-function change enhancing the β cell protective effects mediated by GLP1R activation.Methods: We […]
Read More
Ultra-Processed Foods Directly Linked to Chronic Diseases
Share on PinterestResearchers say there is strong evidence showing that ultra-processed foods promote overeating and increase the risk of obesity. Helene Cyr/Stocksy United A new report states that ultra-processed foods are a major contributing factor to the obesity epidemic. Researchers say these foods are designed to be palatable, causing people to overeat and gain weight. […]
Read More663-P: Associations between Relationship Status and Parenting on Glycemic and Emotional Outcomes in Adults with Type 1 Diabetes (T1D) Enrolled in the GluCog Study
Introduction and Objective: Prior research has shown a link between marital quality and HbA1c in adults with T1D, however, little is known about how parenting impacts glycemic control, including CGM metrics. The aim of the current study was to investigate whether relationship and parenting status impact glycemic outcomes in adults with T1D. Emotional distress was […]
Read More847-P: ASC47, a Muscle-Preserving Weight Loss Drug Candidate for Obesity, in Combination with Semaglutide, Demonstrated Superior Weight Loss to Semaglutide Monotherapy in a Preclinical Model
Introduction and Objective: ASC47 (selective THR-β agonist) is an adipose-targeted, once-monthly subcutaneously (SQ) injected, muscle-preserving weight loss drug candidate for the treatment of obesity, discovered and developed in-house at Ascletis. This study in diet-induced obese (DIO) mice demonstrated a powerful synergy in weight loss and muscle preservation when combining ASC47 and semaglutide.Methods: C57BL/6J mice were […]
Read More662-P: Diabetes Distress, Management, and Psychosocial Needs among Black Young Adults with Type 1 Diabetes from Two Health Care Systems—An Integrated Care System and Public Safety-Net Hospital?
Introduction and Objective: Private integrated healthcare and public safety-net care systems address the medical needs of different socioeconomic (SES) status groups. Irrespective of SES, many young adults with T1D struggle with diabetes management. The study evaluated survey data of Black young adults with T1D in two different healthcare systems to understand psychosocial factors, diabetes care […]
Read More