Category: Diabetes

Introduction and Objective: Insulin resistance (IR) significantly contributes to cardiovascular mortality in type 2 diabetes (T2D). Whether organ-specific IR (skeletal muscle, adipose tissue, liver) independently associates with structural and functional cardiac morbidity and mortality is unclear.Methods: This study included 850 Europeans with and 2243 without T2D of the LUdwigshafen RIsk and Cardiovascular Health (LURIC) cohort […]

Introduction and Objective: Epigenetic modifications, such as DNA methylation(DNAm), can provide a composite measurement of environmental/genetic influence on gene expression. A significant gap remains in defining DNAm profiles in diabetes, prior to DKD diagnosis. We determined blood-derived DNAm profiles, in type-2 diabetes(T2D) people with normal kidney function, that were predictive of DKD incidence in the […]

Introduction and Objective: Coronary artery calcium score (CACS) is an effective marker to stratify cardiovascular risk. Compared to type 2 diabetes (T2D) Ketosis Prone Diabetes (KPD) has an atypical presentation marked by ketosis during decompensation. We compared CACS and cardiovascular events (CVE) in KPD and T2D.Methods: It is a retrospective observational study (2014-2024) of KPD […]

Introduction and Objective: Weight management is essential for preventing type 2 diabetes, particularly in individuals with prediabetes. DNA methylation (DNAm) serves as a biomarker for capturing metabolic changes and disease progression. This study aimed to discover DNAm biomarkers linked to weight loss response in diabetes prevention interventions for individuals with prediabetes.Methods: We analyzed 168 subjects […]

Introduction and Objective: The Chinese diabetes guideline recommends a normal BMI as a component of comprehensive management of T2D. However, evidence on the independent or combined effects of glycemic control and normal BMI on long-term macrovascular outcomes is limited.Methods: Regional electronic health record data from Yinzhou Ningbo China (2006/1/1 – 2021/10/30) was used. Adult patients […]

Introduction and Objective: Mitochondrial dysfunction contributes to cardiovascular and microvascular disease risks in type 2 diabetes (T2D). This study investigates whether mitochondrial DNA copy number (mtDNA-CN) in whole blood can serve as a biomarker for these complications.Methods: mtDNA-CN was measured in the DNA extracted from whole blood samples of 497 T2D adults from the Fenofibrate […]

Introduction and Objective: Overweight/obesity (ow/ob) is increasingly prevalent in T1D, but its impact on vascular complications remains unclear. This study aims to investigate endothelial function in lean (lean T1D) and ow/ob subjects with T1D (T1D+ow/ob), compared to healthy controls.Methods: Endothelial dysfunction was evaluated by flow-mediated dilation (FMD) of the brachial artery and advanced glycation end-products […]

Introduction and Objective: Glycemia management early after liver transplantation (LTx) is challenging due to patients’ critical state and corticoid therapy. We evaluated the impact of actively used real-time continuous glucose monitoring (CGM) on glycemic control in LTx recipients at postoperative ICU in a prospective randomized trial (clinicaltrials.gov NCT05585801).Methods: LTx recipients were randomized to wearing an […]

Introduction and Objective: Coronary artery calcification (CAC), a proxy of atherosclerosis, has increased incidence and prevalence in individuals with diabetes. It is also known that CAC predicts future coronary heart disease, along with mortality in this population. We aimed to evaluate whether the association between diabetes and CAC incidence holds in individuals with diabetes and […]

Introduction and Objective: Inflammation is a key component in the pathogenesis of diabetic peripheral neuropathy (DPN), but underlying mechanisms are poorly understood. We previously identified a nerve-associated macrophage population that responds to neuroinflammatory signaling and expresses the brown adipocyte-related factors beta 3-adrenergic receptor (ADRβ3) and uncoupling protein 1 (UCP1) during tissue regeneration. These studies investigate […]