Category: Diabetes

Introduction and Objective: To evaluate and compare the therapeutic effects of current agents for heart failure with preserved ejection fraction (HFpEF).Methods: Literature retrieval was conducted in PubMed, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrial.gov between inception and December 2024. Randomized controlled trials (RCTs) in patients with HFpEF, which intercompared current therapeutic agents […]

Introduction and Objective: Recent studies highlight the essential role of amino acids in α cell function, with cysteine (Cys) showing the strongest stimulation of glucagon secretion. Diabetic conditions not only elevate glucagon secretion but also alter plasma Cys levels. Hence, the objective was to decipher the mechanistic role of Cys in modulating α cell function.Methods: […]

Introduction and Objective: This study explored anthropometric indicators to improve body mass index (BMI)’s predictive value for cardiovascular (CV) events in individuals without carotid plaques, improving early risk stratification in subclinical populations.Methods: The study included 1043 participants (aged 50-80) from a 2013-2014 community cohort, followed for CV events (2021-2022). Carotid plaque was excluded using ultrasound. […]

Introduction and Objective: Periodontitis (PD), a chronic inflammatory condition, is a leading cause of tooth loss and jawbone deterioration and is associated with an increased risk of diabetes. The persistent inflammation in PD results from an imbalance between pro-inflammatory (M1) and anti-inflammatory (M2) macrophages, contributing significantly to tissue destruction. This study investigates the role of […]

Introduction and Objective: This study aims to examine the gut and oral microbiome characteristics associated with chronic complications in T1D and explore potential links between these microbiomes.Methods: We conducted a cross-sectional study with 74 T1D patients (disease duration >10 years) and 43 healthy controls. Clinical data such as blood glucose, lipids, and complication-related tests were […]

Introduction and Objective: The incidence of gastrointestinal cancers in type 1 diabetes (T1D) patients is higher than in the general population. This study aimed to explore the association between T1D and gastrointestinal cancer, and how it varies by age and sex.Methods: This retrospective cohort study included 268,179 participants from Korean National Health Insurance Service-National Sample […]

Introduction and Objective: Type 1 diabetes (DM1) is associated with poor sleep quality and increased prevalence of obstructive sleep apnea (OSA), leading to worse glycemic control. We aim to assess the impact of sleep disorders on cardio metabolic markers in DM1.Methods: Our retrospective cross-sectional study included patients with DM1 from our endocrinology clinic who underwent […]

Introduction and Objective: Discrepancy between HbA1c and glucose management index (GMI) is usual but its stability over time is unknown.Methods: We analyzed 386 patients with diabetes (83% type 1) in 10 centers. They had continuous glucose monitoring (CGM) with FreeStyleLibre® 1 or 2 (FSL). For each participant, we specifically collected CGM data over 90 days […]

Introduction and Objective: Mitochondrial Rho-GTPase (MIRO1) is a critical regulator of mitochondrial trafficking and calcium homeostasis and by extension, mediates cellular energy balance and intracellular signaling. This study aimed to mechanistically decipher the role of MIRO1 in modulating skeletal muscle insulin action, which has been completely unexplored.Methods: Skeletal muscle MIRO1 KO mice (MIRO1MKO) and littermate […]

Introduction and Objective: CGM has shown promise as a valuable tool for learning and managing blood glucose levels in persons with non-insulin-treated Type 2 Diabetes (PwT2D). This study investigated the insights PwT2D gain regarding the influence of lifestyle factors on blood glucose levels over a two-week period of CGM usage, with minimal instruction and support.Methods: […]