Category: Diabetes

Introduction and Objective: Structured education for type 1 diabetes (T1D) aims to empower individuals to manage their condition effectively. However, limited research has explored the long-term effects of structured education on glycemic improvement, severe hypoglycemia, or diabetic ketoacidosis (DKA). This study assessed the 12-year impact of dose adjustment for normal eating (DAFNE) courses on glycemic […]

Introduction and Objective: Diabetes affects 1 in 10 Americans, highlighting the urgent need for novel therapeutic targets. The insulin receptor (InsR) signaling pathway, classically defined as IRS→ PI3K→ Akt→ FoxO1, is central to glucose regulation. However, evidence suggests an alternative, IRS→Akt-independent mechanism. This study investigates whether BRD7 (bromodomain-containing protein 7) regulates glucose homeostasis via a […]

Introduction and Objective: Despite the proven benefits of continuous glucose monitoring (CGM) in improving diabetes management, its adoption remains limited, particularly in primary care (PC) settings. This underutilization represents a critical gap in healthcare delivery.Methods: A CGM implementation program was launched within a large academic network to educate, train, and support primary care professionals—including residents, […]

Introduction and Objective: GLP-1(32-36), a major end-product of glucagon-like peptide 1 (GLP-1), improves diabetic limb ischemia in mice independent of its insulinotropic effect. However, the mechanisms underlying this effect and its relevance in human ischemic lesions remain unclear.Methods: We used single-cell transcriptomics on the plantar muscles of diabetic foot patients and healthy controls to investigate […]

Introduction and Objective: Satisfaction with medical information plays a critical role in appropriate medication use and is fundamental to pharmacotherapy. This study addresses the lack of data on this important issue in the clinically important population of patients with type 2 diabetes (T2DM) undergoing coronary angiography.Methods: We consecutively enrolled 697 patients who underwent coronary angiography […]

Introduction and Objective: DNA methylation (DNAm) changes have been associated with diabetic retinopathy (DR), but primarily in circulating white blood cells (WBCs). It is critical to determine whether DNAm patterns in WBCs are reflective of those in the retina. We compared DNAm patterns in the retina and WBCs of same individuals of the Joslin Medalist […]

Introduction and Objective: We investigated the role of insulin/IGF1 signaling in cardiac function and lifespan of MDKO mice (Irs1L/L•Irs2L/L•CreMck) generated by MCK (muscle creatine kinase) driven Cre expression in striated and cardiac muscle.Methods: MDKO mice died by 30 days of age with severe cardiomyopathy. Deletion of FoxO1 and FoxO3a in MDKO mice (MQKO mice) slowed […]

Introduction and Objective: GLP-1 and amylin peptide hormones independently reduce food intake, delay gastric emptying, and decrease glucagon release. Combination of GLP-1 and amylin analogs promotes greater weight loss and glycemic control than either agent alone. Here we assessed the in vivo efficacy of a novel oral amylin analog (VRB103) in rodent models, as well […]

Introduction and Objective: Wall shear stress (WSS), the force exerted by blood flow on vessel walls, is considered an early indicator of atherosclerosis, as moderate WSS supports endothelial function. It has been reported that WSS is associated with cerebral small vessel disease (SVD). Traditional methods like MRI and computational fluid dynamics assess WSS but are […]

Introduction and Objective: Black women in the U.S. women are disproportionately affected by type 2 diabetes. This disparity partly stems from gaps in clinical diabetes risk screening and education. Hair salons are community settings that are frequented by Black women and could offer unique opportunities to implement diabetes education and prediabetes screening in a trusted […]