Introduction and Objective: Type 1 Diabetes Mellitus (T1DM) poses a significant health challenge for youth globally. This study examines mortality trends in ages 15-39 from 1990 to 2021.Methods: GBD data were analyzed to assess the mortality rates per 100,000 of T1DM in individuals aged 15-39. The Estimated Annual Percentage Change (EAPC) was used to evaluate trends from 1990 to 2021, with p-values determining the statistical significance.Results: The global prevalence of T1DM increased from 1990 to 2021, peaking in 2021. India recorded the highest prevalence (1,244,397.45, UI: 949,571.19-1,656,589.25), followed by the USA and China. In 2021, Haiti had the highest mortality rate (2.43, 95% CI: 1.40-3.96), slightly lower than its 1990 rate (2.89, 95% CI: 2.02-4.98), the second highest that year. Trinidad and Tobago (2.13) and Mauritius (2.07) followed. The lowest mortality rates were observed in Singapore (0.047, 95% CI: 0.04-0.05), Italy (0.089), and Spain (0.1). Countries with the largest EAPC increases included Brazil (0.95, CI: 0.84-1.05), Lesotho (0.95), and Mexico (0.94). The greatest declines were seen in Singapore (-0.81), the Republic of Korea (-0.76), and Luxembourg (-0.75).Conclusion: T1DM mortality rates among individuals aged 15-39 increased globally from 1990 to 2021, notably in Brazil, Lesotho, and Mexico, emphasizing the need for improved prevention, management, and research on underlying disparities.
H. Ahmad: None. M. Kakakhel: None. A. Qadeer: None. S. Ishtiaq: None. A. Khan: None. S. Zain: None. R.W. Kirchoff: None.
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