Author: sugaradmin

Introduction and Objective: GCGR agonism stimulates energy expenditure (EE) and weight loss in rodents. Moreover, when combined with the antidiabetic actions of incretins (GLP1, GIP), GCGR-agonists lack hyperglycemic side effects. We also identified anti-obesity effects of GCGR agonism for 50d after treatment cessation. Thus, we hypothesized that a GLP-1/GIP/GCGR triple agonist (GGG) will increase EE […]

Introduction and Objective: Personality may influence key glycemic, behavioral, and emotional outcomes in people with T1D. We investigated Five-Factor Model (FFM) personality traits as predictors of self-management (SM), diabetes distress, and continuous glucose monitoring (CGM) metrics among 187 diverse adults with T1D.Methods: Participants wore CGM and rated their SM (each evening on a 0-100 scale) […]

Introduction and Objective: Insulin resistance (IR) and higher BMI are associated with the development of MASLD. However, their independent association with “at-risk” MASLD (i.e., steatohepatitis with clinically significant fibrosis or stage ≥F2; MASLD≥F2) is unclear. We investigated how IR and obesity interact to impact MASLD severity.Methods: We divided 283 individuals without diabetes into having overweight […]

Introduction and Objective: The growing prevalence of diabetes underscores the need for scalable, patient-centric tools to support diabetes self-management and education (DSME). Mitraa, a GPT-based conversational AI model, was developed to provide personalized diabetes care, including guidance on nutrition, medication adherence, glucose monitoring, and lifestyle adjustments. This study validates Mitraa’s effectiveness in delivering accurate, patient-relevant […]

Introduction and Objective: Type 2 diabetes (T2D) is often associated with metabolic dysfunction-associated steatotic liver disease (MASLD) which may lead to clinically significant fibrosis (defined as moderate-to-severe fibrosis stage ≥F2 or “at-risk” MASLD≥F2) and eventually cirrhosis. The role of insulin resistance (IR) in the development of MASLD≥F2 remains unclear. We examined the relationship of IR […]

Introduction and Objective: Chronic diseases like diabetes strain healthcare systems among Saudi MEDGULF insured population. Traditional clinical guidelines and advanced AI-driven methods often exist in silos, hindering comprehensive management. This study introduces an Integrated Clinical-AI Stratification Framework that unifies evidence-based clinical protocols with AI models to enhance early detection, individualized risk stratification, and personalized interventions […]

Introduction and Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with “at-risk” MASH (steatohepatitis with significant fibrosis stage ≥F2) and cirrhosis. Magnetic resonance (MR) iron-corrected T1 mapping (cT1) allows for improved MASH risk stratification, but whether it may help define their metabolic profile needs further validation.Methods: We measured AST, ALT, HbA1c, insulin, FFA, liver […]

Introduction and Objective: Acute elevation of non-esterified fatty acids (NEFA) can induce peripheral insulin resistance and impair glucose uptake in muscle. Rodent studies have shown that elevation of NEFA through a high-fat diet impairs brain glucose uptake, and prior observational studies by our group have reported that higher NEFA levels correlate with lower brain glucose. […]

Introduction and Objective: Hepatic stellate cells (HSCs) play a key role in developing insulin resistance. While Rho-kinase 1 (ROCK1) activation in hepatocytes promotes obesity-induced insulin resistance, the physiological role of ROCK1 in HSCs remains unclear. This study investigated the importance of ROCK1 in HSCs in the context of obesity-related metabolic dysfunction.Methods: Mice lacking ROCK1 in […]

Introduction and Objective: It has been suggested that infection may contribute to T1D development via extended exposure of islets to proinflammatory cytokines. Recent evidence, however, suggests that the primary effects of cytokine signaling in islets may be protective through the upregulation of antipathogen and antioxidant genes in β-cells. This study tests the hypothesis that there […]