Author: sugaradmin

Introduction and Objective: The present study aims to determine the relationship between insulin secretion pattern after glucose load in the early postpartum period (< 6 months) and the incidence of abnormal glucose metabolism (AGM) in the future among women with a history of gestational diabetes mellitus (GDM).Methods: This is a prospective cohort study that conducted […]

Introduction and Objective: Despite promising incretin therapies for type 2 diabetes (T2D), many humans with T2D respond poorly to incretins, and the underlying mechanism is unclear.Methods: Human islets with GPT2 silencing and β-cell-specific Gpt2 knockout mice (Gpt2βKO) were used to study incretin response and β-cell survival.Results: We report that mitochondrial transaminase GPT2 was induced in […]

Introduction and Objective: People with excess weight have a different susceptibility to type 2 diabetes. Underlying mechanisms explaining those differences are still a matter of debate. Our aim was to determine whether insulin sensitivity and secretion could be related to a spectrum of metabolic parameters.Methods: The subjects were healthy volunteers or patients with overweight/obesity seeking […]

Introduction and Objective: One-third of chronic pancreatitis (CP) patients who undergo total pancreatectomy with islet autotransplantation (TPIAT) achieve insulin independence. Little is known regarding diabetes (DM) related genetics on TPIAT. Genetic risk scores (GRS) are utilized in type 1 (T1D) and type 2 (T2D) DM to predict C-peptide (Cpep) before diagnosis.Methods: We genotyped 384 patients […]

Introduction and Objective: Subtypes of type 2 diabetes (T2D) identified at diagnosis differ in risks of diabetes complications. We modeled their metabolic trajectories preceding diagnosis to inform subtype membership and pathophysiology.Methods: From cohort studies (ARIC, CARDIA, DPP/OS, JHS, MESA), we subtyped individuals with newly diagnosed T2D (n = 2,691; age = 63 years [SD: 12], […]

Introduction and Objective: Neutral sphingomyelinase 2 (nSMase2) is a crucial enzyme involved in several important cellular processes, including exosome formation, ceramide production, cellular stress responses, and inflammatory signaling responses. However, impacts on beta cell health are unknown.Methods: INS-1 823/13 nSMase2 knockdown cells were generated by transfecting plasmids with rat nSMase2 shRNA containing a GFP reporter. […]

Introduction and Objective: Automated insulin delivery (AID) systems provide enhanced glycemic benefits and reduce diabetes care burden. We implemented a QI initiative aimed at increasing AID use in youth with new-onset T1D (<1 yr) at a large pediatric diabetes center from baseline of 5% in Jan 2022 to >25% by Nov 2024. As a balancing […]

Introduction and Objective: Islet transplantation is a promising therapeutic approach for people with unstable T1DM. The main challenge is to reduce the number of pancreases needed to treat a single person. In this context, we have recently demonstrated that ILV-001, a component of the muscle secretome, enables rapid uptake and lasting function of the graft. […]

Introduction and Objective: While the Veterans Affairs (VA) MOVE! Program (DPP-like lifestyle intervention) demonstrated a 24% relative risk reduction in type 2 diabetes (T2D) over 15 years, individual responses varied substantially. We examined this heterogeneity of effects.Methods: Using 2005-2024 VA electronic health records data, we identified NDPP-eligible veterans who enrolled in MOVE! from 2005 to […]

Introduction and Objective: While continuous glucose monitoring (CGM) can enhance diabetes (DM) management, its impact on outpatient, high-cost complications is understudied, particularly in community health centers (CHCs).Methods: Using electronic health record data from a national CHC network, we examined demographic characteristics, care utilization (number of visits and telehealth use), CGM use, and outpatient acute DM […]