Author: sugaradmin

Introduction and Objective: Patients with type 2 diabetes (T2D) are at increased risk of acute pancreatitis (AP) and biliary events. Existing evidence is mixed regarding the association between second-line diabetes medications and AP and biliary events.Methods: Using Medicare and 2 U.S. private health plans (2014-2021), we identified three pairwise cohorts of propensity score (PS) fine […]

Introduction and Objective: The association between sedentary behavior (SB) and glycemic profiles in individuals with type 1 diabetes (T1D) is unclear. This study aimed to examine this relationship cross-sectionally.Methods: Ninety-three Japanese adults with T1D participated in this study (75 women; age: 45.0 [36.0-55.0] years, HbA1c: 7.3 [6.8-8.1] %, median [25%-75% quartiles]). Physical activity (PA) was […]

Introduction and Objective: Adverse childhood experiences (ACEs) are known to impact the health and well-being of those living with T1D. Less is known regarding how ACEs of a primary caregiver (parent, grandparent, etc.) may indirectly impact youth with chronic health conditions – potentially via influence on parenting practices. The current study investigates the relationship between […]

Introduction and Objective: Physical activity (PA) is a well-known intervention resulting in weight loss, improved physical fitness and metabolic parameters, thereby contributing to reduced risk of conditions such as type 2 diabetes, cardiovascular disease, hypertension, and hyperlipidemia. Interventions promoting healthy lifestyle are more likely to succeed if they are culturally tailored. The goal of this […]

Introduction and Objective: Severe hypoglycemia (SH) poses a significant threat to persons with diabetes, with evidence of 30-40% of patients with type 1 diabetes (T1D) and 1-in-5 individuals with type 2 diabetes (T2D) experiencing severe events annually. Alarmingly, prescriptions for ready-to-use (RTU) glucagon remain drastically low: 22.4% of patients at increased risk currently receive RTU […]

Introduction and Objective: The incidence of type 2 diabetes (T2D) in younger adults is increasing, yet physical activity engagement in this population is underexplored. This study used co-design to develop a complex intervention to improve physical activity levels in people with young-onset T2D (18-40 years).Methods: Development involved three stages. Stage 1 extracted evidence from a […]

Introduction and Objective: The amount and rate of CO2 produced versus O2 consumed, called respiratory quotient (RQ), indicates the type and quantity of metabolic substrate utilized by the body and may be used as a marker of blood glucose estimation. We developed a hand-held device (Breath-AI V3) that measured end tidal breath CO2 along with […]

Introduction and Objective: Data indicate that the time of day at which exercise is performed may modulate glucose responses to resistance exercise, although limitations mean certainty of evidence is low. The objective of the current study, therefore, is to compare glucose responses to a bout of resistance exercise performed in the morning or in the […]

Introduction and Objective: The GRADE trial compared four glucose-lowering drugs for HbA1c reduction in individuals with type 2 diabetes mellitus (T2DM) on metformin monotherapy but lacked a sodium-glucose cotransporter-2 inhibitor (SGLT-2i) arm. We emulated GRADE including SGLT-2i & excluding insulin.Methods: In a US commercial claims database (2014-2023), we used propensity score weighting to balance 87 […]

Introduction and Objective: Exercise increases hypoglycemia risk in people with T1D. Pre exercise whey protein ingestion, which stimulates glucagon secretion and endogenous glucose production, may be a novel strategy to mitigate hypoglycemia with exercise in T1D.Methods: Three adults with T1D (mean ± SD HbA1c 6.6 ± 0.3%) using MiniMed 780G underwent two bouts of moderate […]