574-P: A Comparison of the Effects of Morning and Afternoon Exercise on Glucose Control in People with Type 1 Diabetes—A Randomized Crossover Trial

by sugaradmin



Introduction and Objective: Data indicate that the time of day at which exercise is performed may modulate glucose responses to resistance exercise, although limitations mean certainty of evidence is low. The objective of the current study, therefore, is to compare glucose responses to a bout of resistance exercise performed in the morning or in the afternoon in people with type 1 diabetes.Methods: In a randomized cross over trial people with type 1 diabetes performed three acute bouts of resistance exercise in the 1) morning (6am-10am) in a fed state, 2) morning in a fasted state and 3) afternoon (3pm-8pm) in a fed state, with interstitial glucose responses measured, via continuous glucose monitoring (CGM) for 6-h post exercise and in the nocturnal period (11pm-6am). A repeated measures ANOVA and post-hoc paired t-tests was conducted to compare the effect of the three exercise sessions on CGM data.Results: We recruited 59 people with type 1 diabetes to the study (aged 21-64 years). In multiple daily injections (MDI) users (n=42), but not insulin pump users (n=17), mean glucose levels were higher in the 6-h period after morning fasted and fed sessions (fasted: 9.48 ±2.63 mmol/L, fed: 9.27 ±2.31 mmol/L) compared to afternoon fed session (8.34 ±1.98 mmol/L). In MDI, but not insulin pump, users time in range was lower (52.1% vs 66.6%, p = 0.026) and time above range (43.8% vs 29.4%, p = 0.036) was higher in morning fasted vs afternoon fed sessions. In the nocturnal hours, time in range was higher in insulin pump, but not MDI, users after the morning fasted compared to afternoon fed sessions (72.4% vs 43.9%, p = 0.03). No other differences between the sessions were noted.Conclusion: The time at which resistance exercise was performed results in differential glucose responses in people with type 1 diabetes. This may allow optimization of exercise prescription, based on the time of day, in this population.

Disclosure

Y. Hamdan: None. N. AlOtaibi: None. J. AlKandari: None. D. Taliping: None. E. Taghadom: None. A. AlAwadhi: None. S.R. Gray: None. E. Al-Ozairi: None.

Funding

Kuwait Foundation for the Advancement of Sciences (KFAS), Kuwait



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