Month: June 2026

Introduction and Objective: Obesity is a major driver of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), conditions with substantial unmet medical need. This study aimed to characterize XWDAPC-1, a novel long-acting β-klotho antibody-GLP-1/GCG/GIP quadragonist, for its metabolic efficacy and pharmacological profile.Methods: The in vitro activity of XWDAPC-1 was evaluated using cell-based […]

Introduction and Objective: An unhealthy diet is associated with obesity, cardiovascular disease and death. Zenagamtide (previously amycretin) is a novel unimolecular GLP1-, amylin- and calcitonin receptor agonist that decreased body weight by up to 24.3% in patients with obesity. As it is unknown if zenagamtide also promotes healthier food choices, we investigated zenagamtide’s distribution to […]

Introduction and Objective: Type 2 diabetes (T2DM) places older adults at risk of unhealthy aging and cognitive decline. Diabetes self-management education and support (DSME/S) is effective but underutilized. We conducted a two-arm randomized trial (DSME/S delivery via an immersive, 3D virtual environment (HOPE) versus a waitlist control group) to assess 6-month changes in glucose control […]

Introduction and Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major global health challenge with limited effective pharmacological therapies. Although lysine lactylation has emerged as an important regulator of metabolic homeostasis, whether lactylation of the key glycolytic enzyme phosphofructokinase liver type (PFKL) drives MASLD progression and the underlying mechanisms remain obscure.Methods: Quantitative lactylome and […]

Introduction and Objective: Evidence for GLP-1RA-associated cardiovascular benefits in type 1 diabetes (T1D) remains scarce. Using a target trial emulation, we assessed the impact of GLP-1RA use on cardiovascular outcomes in a high-risk cohort of adults with T1D and overweight or obesity.Methods: We emulated a target trial using electronic health records from Epic COSMOS database. […]

Introduction and Objective: MASLD is a common polygenic condition, but current GWASs have only identified 14 loci due to a lack of scalable, clinically relevant phenotypes.Methods: Using machine learning on four UKBB data modalities (MRI, DXA, plasma metabolites, blood biomarkers; n=25,474 to 262,927), we predicted liver fat (LF) and adipose tissue volume (ATV), increasing statistical […]

Introduction and Objective: The organization’s transitional care center (TCC) has reduced overall rehospitalizations. Initiative evaluated whether DM nurse practitioner (NP) led post-discharge management in TCC, coupled with CHW support with SDOH barriers, reduces 90-day healthcare utilization and costs among people hospitalized with diabetes, compared to 90 days prior to index admission.Methods: In 2025, DM NP […]

Introduction and Objective: Post-pancreatitis diabetes mellitus (PPDM-C) is characterized by dual exocrine and endocrine failure. However, the impact of exocrine insufficiency (PEI) on β-cell reserve and glycemic variability remains underdefined. This study aims to elucidate the characteristics of islet function in CP and the influence of exocrine status on glucose homeostasis.Methods: We analyzed 148 CP […]

Introduction and Objective: Effective care models are needed for youth with type 2 diabetes (YT2D). Shared medical appointments using group education modules benefitted youth with T1D. This study aimed to design group education modules called Team Clinic for T2D (TCT2) with input from primarily Latinx, publicly insured YT2D, caregivers, and clinicians.Methods: An iterative human-centered design […]

Introduction and Objective: A recent study comparing Freestyle Libre (FSL) 3, Dexcom (Dex) G7, and Medtronic (Med) Simplera CGM systems found discordant glycaemic metrics, with Med showing a significantly lower glucose management indicator (GMI) and a higher time-in-range. The purpose of this study was to assess concordance between laboratory HbA1c and GMI from three sensor […]