Month: June 2026

Introduction and Objective: All-cause mortality has been on the decline among people with type 1 diabetes (T1D). Despite this trend, excess mortality remains high among people with T1D compared to those without T1D. We examined the all-cause and cause-specific mortality in a contemporary T1D cohort and explored factors that influenced mortality.Methods: Participants in the Coronary […]

Introduction and Objective: Annual eye examinations for diabetes (EEDs) are essential for early detection of diabetic retinopathy, yet adherence remains suboptimal, particularly in rural communities where access to eye care is limited. Autonomous AI systems offer a scalable approach to expand patient access at the point of care. We evaluated the real-world impact of LumineticsCore™, […]

Introduction and Objective: Rapid postprandial glucose rises during pregnancy may adversely affect offspring health, while practical dietary advice for gestational diabetes remains limited. In type 2 diabetes, premeal whey protein (WP) reduces postprandial blood glucose. We investigated whether preprandial WP attenuates glucose excursions after carbohydrate intake in pregnant women and explored underlying mechanisms.Methods: In this […]

Introduction and Objective: PVHMC4R and PBNMC4R neurons are central to the regulation of energy intake and glucose metabolism, yet the neurocircuit mechanisms underlying glycemic control at these neural nodes remain unclear. Here, we investigated whether a PVHMC4R → PBNMC4R neurocircuit contributes to glucoregulation using an intersectional viral mapping approach.Methods: To anatomically define this pathway, we […]

Introduction and Objective: Lifestyle-related circadian disruption, including night-shift work, increases susceptibility to obesity and type 2 diabetes. However, the long-term effects of maternal circadian misalignment during pregnancy on metabolic health of adult offspring remain unclear. We investigated whether gestational circadian disruption, modeled using a short-day (SD) light cycle, programs offspring for metabolic dysfunction.Methods: Pregnant C57BL/6J […]

Introduction and Objective: Reversion to normoglycemia is increasingly recognized as a key goal in pre-diabetes management. Weight loss is a vital strategy to facilitate prediabetes reversion. This study assessed the association of weight change patterns with prediabetes reversion.Methods: Data were from the China Health and Retirement Longitudinal Study Waves 1-3 (2011, 2013, and 2015). Participants […]

Introduction and Objective: Diabetes-related stigma in healthcare professionals has been shown to negatively affect the mental health, disease self-management, and clinical outcomes (e.g., HbA1c) of people with diabetes. However, little is known about how this stigma varies among medical students. Understanding these differences is crucial for identifying future healthcare professionals most vulnerable to stigmatized attitudes […]

Introduction and Objective: Hypokalemia is associated with adverse cardiovascular outcomes in heart failure (HF) and may impair insulin release and action. However, whether hypokalemia promotes incident diabetes in HF is uncertain.Methods: In this FINEARTS-HF analysis, we evaluated the association between time-updated serum potassium levels and new-onset diabetes, defined as ≥2 HbA1c measurements ≥6.5% or initiation […]

Introduction and Objective: The rate of hypertensive disorders of pregnancy (HDP) is rising. HDP has been linked to pre-existing cardiometabolic (CM) risk factors, including insulin resistance (IR), BMI, blood lipids, and lactate. Therefore, we sought to understand if an association exists between these markers in early pregnancy and development of HDP in our population.Methods: This […]

Introduction and Objective: To investigate the associations between immune cell subset frequencies and metabolic features (including islet autoantibodies, fasting C-peptide [FCP], and HbA1c) in patients with type 1 diabetes (T1D) in China.Methods: This cross-sectional study enrolled 204 participants diagnosed with T1D. Flow cytometry was used to measure the immune cell subset (T/B/NK cells, Th cells, […]