Month: June 2026

Introduction and Objective: Despite the increased use of wearable technologies for self-management of type 1 diabetes, patients and families do not commonly download and review their data between clinic visits. The Diabetes, Data & Devices (D3) Education Program was developed to address this gap by providing structured education on diabetes data review and interpretation. This […]

Introduction and Objective: The benefits of diabetes self-management education and support (DSMES) are well-established. State Medicaid programs provide DSMES coverage. The objective was to obtain actionable data on utilization of DSMES among Medicaid enrollees with diabetes to inform strategies to increase use of services.Methods: This serial cross-sectional study analyzed Transformed Medicaid Statistical Information System (T-MSIS) […]

Introduction and Objective: Adolescents with type 1 diabetes (T1D) require contextually-aware, evidence-based self-management support. General-purpose large language models (LLMs) lack integration with systematically synthesized and appraised evidence or contextual tailoring. This study aimed to construct and evaluate T1DiaBot, a knowledge graph-grounded agent designed for adolescents with T1D.Methods: A self-developed “Evidence-to-Performance” (E2P) framework was followed: 1) […]

Introduction and Objective: Hypoglycemia causes an adrenergic response (AR) associated with epinephrine rise. We evaluated if change in heart rate (ΔHR), used as surrogate for AR, can distinguish between symptomatic and asymptomatic sensor-detected hypoglycemia (SDH), and factors affecting this, in type 2 diabetes. We focused on awake, symptomatic SDH<54mg/dL from people with intact awareness (Gold≤3), […]

Introduction and Objective: Accurate forecasting of continuous glucose monitoring (CGM) trajectories can support proactive diabetes management. We evaluated time-series foundation models (FMs) for CGM forecasting in two populations: type 1 diabetes and a combined non-diabetes/type 2 diabetes group. We assessed whether adding multimodal dietary context improves predictive performance.Methods: Using 8 CGM datasets, we compared FMs […]

Introduction and Objective: The overconsumption of fructose-rich western diets can cause metabolic dysfunction-associated kidney disease (MDAKD). We recently reported that high-risk Xor variants increase Xor and predispose to kidney disease in susceptible DBA/2J and B6Xorem1 vs. resistant C57BL/6J (B6) mice, with diabetes. However, the role of Xor risk variants in fructose-induced MDAKD has not been […]

Introduction and Objective: Novel once-weekly therapies targeting complementary pathways, such as basal insulin and GLP-1 RA, may simplify management and improve outcomes in type 2 diabetes (T2D). This study aimed to evaluate the short-term effects of icodec plus tirzepatide in a real-world setting.Methods: This retrospective observational study included 21 adults with long-standing T2D initiating icodec […]

Introduction and Objective: Tumor necrosis factor (TNF)-alpha signaling is associated with obesity and insulin resistance, although its role in beta-cell function has not been addressed. The TNFRSF1A gene encodes the tumor necrosis factor receptor 1 (TNFR1;p55), which is bound by the cytokine TNF-alpha. Signaling through this pathway activates the NF-κB pathway and overactive inflammatory pathway […]

Introduction and Objective: Patients with type 1 Diabetes (T1D) increasingly exhibit metabolic syndrome features, a phenotype termed “Double Diabetes.” We investigated the interaction of HbA1c and BMI with cardiovascular (CV) risk factors in a large cohort.Methods: This is a cross-sectional analysis of 1,266 persons living with T1D. CV risk was quantified by a composite score […]

Introduction and Objective: Incidence of diabetes in youth is expected to increase in the US and surveillance efforts have faced challenges. Using comprehensive electronic health record data from Kaiser Permanente Southern California (KPSC), we estimated diabetes incidence in youth 0-17 years from 2018-2024.Methods: Denominators included membership counts of youth <18 years on December 31 of […]