Month: July 2025

Introduction and Objective: Polygenic risk scores (PRS) are emerging as a novel tool for prevention and management of cardio-renal-metabolic (CRM) disease. In this study, we describe results from the first year of implementing clinical PRS testing for CRM disease in a large community health system.Methods: CLIA-certified PRS testing for type 1 diabetes, type 2 diabetes, […]

Introduction and Objective: Single-cell RNA sequencing (scRNA-seq) analysis of pancreatic islet tissues is powerful for studying Type 1 and Type 2 Diabetes (T1D and T2D). Despite many existing efforts, individual datasets are modest in size and fragmented across donors, labs and conditions, highlighting the need for a single-cell (SC) atlas that collates information from diverse […]

Introduction and Objective: The Diabetes Belt, spanning 644 counties across 15 southern states, faces disproportionately high rates of type 2 diabetes, compounded by limited health literacy and systemic inequities. This study investigates how health educators employ leadership and behavior change theories—transformational leadership, transactional leadership, the transtheoretical model, and diffusion of innovation—to design effective interventions. The […]

Introduction and Objective: The objective of this study was to compare the performance of Tc-99m WBC SPECT/CT and MRI in subjects with suspected diabetic foot osteomyelitis (DFO) using bone biopsy as a reference standard.Methods: In total, 47 subjects with suspected DFO underwent MRI and Tc-99m WBC SPECT/CT imaging prior to bone biopsy. Subjects with soft […]

Introduction and Objective: While clinical trials have established legacy effects in diabetes management, real-world evidence on how historical glycaemic exposures affect survival and critical time windows is limited. We evaluated the legacy effect of glycaemic exposure on all-cause mortality among newly diagnosed type 2 diabetes (T2D).Methods: This was a retrospective cohort of 52,404 newly diagnosed […]

Introduction and Objective: Cardio-renal complications are the leading source of morbidity in people with type 1 diabetes (T1D). While previous metabolomic studies have characterized incident and predictive metabolic signatures (metabotypes) of diabetic kidney disease (DKD) and cardiovascular autonomic neuropathy (CAN) in separate T1D cohorts, no previous study has investigated CAN and DKD in the same […]

Introduction and Objective: Sugar-sweetened beverages (SSBs) consumption has emerged as a critical public health concern globally. However, comprehensive analysis of its long-term impact on diabetes mellitus and chronic kidney disease (CKD) mortality across different socio-demographic contexts remains limited.Methods: Using Global Burden of Disease Study 2021 data, we analyzed SSB-attributable diabetes and CKD mortality trends across […]

Introduction and Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) with diabetes has grave health implications. The FAST score is a widely used tool for assessing MASLD severity. However, its relationship with indices such as TyG INDEX, TyGWHtR, BMI, and WHtR remains unclear. This study evaluated the predictive value of these indices for MASLD severity using […]

Introduction and Objective: Diabetic Kidney Disease (DKD) occurs commonly in people with diabetes and often presents with albuminuria resulting from glomerular filtration barrier injury. The glycocalyx, an extracellular matrix (ECM) produced by endothelial cells, plays a critical role in regulating glomerular filtration.Methods: To test if diabetes induces ECM changes, we examined the abundance of glomerular […]

Introduction and Objective: To explore the incidence of emergency hospitalization among young-onset diabetes using a nationwide registry database.Methods: Based on the Korean National Health Insurance Service-National Sample Cohort database from 2006 to 2019, data were collected for patients aged ≤30 years with type 1 (T1D) and type 2 diabetes (T2D). The risks of emergency hospitalization […]