Introduction and Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) with diabetes has grave health implications. The FAST score is a widely used tool for assessing MASLD severity. However, its relationship with indices such as TyG INDEX, TyGWHtR, BMI, and WHtR remains unclear. This study evaluated the predictive value of these indices for MASLD severity using FAST scores in people with diabetes.Methods: A multicentric analysis of 335 people with type 2 diabetes was conducted (50.8% males, 49.2% females, mean age 50.3 years, mean HbA1C 8.9%, mean duration of diabetes 7.9 years). Indices analyzed included TyG INDEX (Triglyceride glucose index) TyG WHtR(Triglyceride glucose-waist to height ratio), BMI, WHtR, and metabolic markers (e.g., TG/HDL ratio, Non HDL/HDL ratio). FAST scores of >0.35 were considered intermediate to high risk.Results: The cohort had a mean BMI of 27.2 kg/m2 and WHtR of 0.56. FAST scores indicated that 27.9% of individuals were at intermediate to high risk. WHtR had the strongest correlation with FAST scores (R = 0.183, p = 0.0008), followed by BMI (R = 0.177, p = 0.0014) and TyGWHtR (R = 0.161, p = 0.003). TyG INDEX showed no significant correlation. Other markers, including Non HDL/HDL ratio,TG/HDL ratios, demonstrated weak nonsignificant correlations.WHtR outperformed BMI,TyGWHtR outperformed TyG index as a predictor of FAST scores, although correlations were weak.Conclusion: WHtR showed a higher predictive value as compared to BMI. Incorporating WHtR in TyG index increased its predictive value.
A. Tewari: None. J. Tewari: None. V. Tewari: None. M. Anuj: None.
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