Month: July 2025

Introduction and Objective: Of the many complications of diabetes, cardiovascular disease (CVD) is one of the deadliest. In many studies, hyperglycemia has been shown to cause endothelial cell dysfunction. While there are numerous studies which elucidate the molecular mechanisms by which hyperglycemia affects the vasculature, few studies have investigated how hyperglycemia affects the mechanical function […]

Introduction and Objective: Persistence with the injectable glucagon-like peptide-1 receptor agonist (GLP-1RA) semaglutide for weight management has been studied extensively, but drivers of persistence are not well characterized. We sought to identify predictors of persistence in a US real-world population.Methods: Adults (≥18 years old) who had a first claim for semaglutide for weight management (index […]

Introduction and Objective: With half the global population predicted to be obese by 2035, understanding the role of adiposity on obesity-associated comorbidities is critical. Adipose tissue (AT) inflammation negatively affects atherosclerosis, insulin resistance, and metabolic-associated fatty liver disease, but the mechanism behind interorgan signaling remains a mystery. Extracellular vesicles (EVs) deliver bioactive cargo to alter […]

Introduction and Objective: Tirzepatide (TZP), a dual GIP-R and GLP-1R agonist, has demonstrated outstanding efficacy in glycemic control and weight loss. Structural studies have demonstrated the binding mechanism between tirzepatide and the GLP-1R-wilt type (WT). However, since population studies have demonstrated multiple SNPs on the GLP-1R, the mechanisms of TZP binding to GLP-1R variants have […]

Introduction and Objective: We showed that genetic variability in the PPARA region influences the effectiveness of the PPAR-α agonist fenofibrate on CVD and diabetic retinopathy (DR) progression, even in subjects without atherogenic dyslipidemia. Evidence suggests that higher genetically determined PPARA expression (Genetic Score (eQtGS) of PPARA retinal expression) may contribute to greater fenofibrate benefit. Here, […]

Introduction and Objective: Decreased insulin sensitivity (resistance) is associated with higher T2D risk. Identifying reliable surrogate indexes that are convenient and that use standard clinical assays might improve prevention of T2D. We compared the ability of 15 indexes to predict future T2D in Southwest US American Indians.Methods: We calculated indexes obtained from oral glucose tolerance […]

Introduction and Objective: The large-conductance Ca2+-activated K+ (BK) channel is critical in regulation coronary circulation, with its expression tightly regulated by Sorbin and SH3 domain-containing protein 2 (Sorbs2). Sorbs2 expression is downregulated in coronary arteries, contributing to BK channelopathy and vasculopathy in diabetic animals. However, the role of Sorbs2 in BK channel function in human […]

In this special episode on Treatment of Hypercortisolism in Uncontrolled Diabetes our host, Dr. Neil Skolnik, will discuss new evidence showing the surprising prevalence of Hypercortisolism in people with uncontrolled Type 2 Diabetes, and the effect of treatment.  This special episode is supported by an independent educational grant from Corcept. Presented by: Neil Skolnik, M.D., […]

Introduction and Objective: The proliferation of preadipocytes favors global metabolic homeostasis. Our study aims to explore the role of mitochondrial protein Optic atrophy 1 (OPA1) in preadipocytes in regulating metabolic disorders and elucidate underlying mechanisms.Methods: We generate preadipocyte-specific KO mice (OPA1PKO) with OPA1flox/flox and Pdgfrα-Cre mice and overexpression mice (OPA1OE) by AAV-DIO injection in Pdgfrα-Cre […]

Introduction and Objective: Diabetic peripheral atherosclerosis is an important marker of macrovascular complications in diabetes. Changes in the thickness of carotid atherosclerotic plaques can indicate early macrovascular alterations in diabetes. The aim of this study is to observe the impact of PCSK9 inhibitors (PCSK9i) on changes in carotid plaque thickness in patients with diabetes without […]