Month: July 2025

Introduction and Objective: Aryl hydrocarbon receptor (AHR) serves as a crucial molecular pathway that is regulated by both endogenous and environmental small molecules to shape the immune response and contribute to the onset of autoimmune diseases. AHR also offers a potential target for therapeutic intervention in immune-mediated disorders. Tryptophan metabolite ITE functions as an endogenous […]

Introduction and Objective: This study examines changes in treatment satisfaction and glycemic outcomes in people with type 1 diabetes (PwT1D) transitioning from multiple daily injections (MDI) to continuous subcutaneous insulin infusion (CSII) with the tubeless Accu-Chek Solo micropump.Methods: CSII-naive PwT1D from Argentina (n=50) were enrolled in a multi-center, prospective, single-armed study using Accu-Chek Solo with […]

Introduction and Objective: We aimed to identify candidate placental proteins that impact beta-cell function in human pregnancy through transcriptome-wide placental gene expression analysis.Methods: In the Gen3G cohort, we measured glucose and insulin levels fasting, 1, and 2 hours after a 75-gram oral glucose load given at 24-30 weeks’ gestation. We calculated the Pregnancy Insulin Physiology […]

Introduction and Objective: SGLT2 inhibitors are efficacious in patients with T2D, renal dysfunction, and heart failure; yet their use in patients with T1D is limited due to increased risk of DKA despite demonstrating improvement in A1c and percent glucose time in range. To understand the molecular basis of SGLT2i-mediated DKA risk, we performed comprehensive plasma […]

Introduction and Objective: Erythropoietin (EPO), a glycoprotein cytokine primarily produced in the kidneys in response to hypoxia is required for erythrocyte production, promotes erythroid differentiation and increases glucose uptake in erythroid progenitor cells in culture. The discovery that its receptor (EPOR) is expressed on both hematopoietic and non-hematopoietic tissues has led to research expanding our […]

Introduction and Objective: Sodium Glucose Cotransporter-2 Inhibitors, or SGLT2is, are an anti-hyperglycemic medication with indications for diabetes, HF and CKD. SGLT2i usage is associated with increased risk for diabetic ketoacidosis (DKA), and we conducted a retrospective analysis for patient quality improvement at our hospital system. Our findings indicate a relationship between demographic identity variables and […]

Introduction and Objective:Xist, a long non-coding RNA essential for X chromosome inactivation (XCI) in female mammals, ensures dosage compensation of X-linked genes. Beyond XCI, Xist is implicated in immunity, cell proliferation, and obesity, a major risk factor for type 2 diabetes (T2D). This study explores Xist’s role in metabolism using mouse models.Methods: We developed mouse […]

Introduction and Objective: DPNP is a debilitating diabetes complication affecting ~30% of people with type 1 (T1D) or type 2 (T2D) diabetes. Current therapies offer limited relief with frequent adverse effects highlighting the need for innovative approaches.Methods: PROGRESS was a phase 2b study evaluating the efficacy and safety of pilavapadin (LX9211), a non-opioid inhibitor of […]

Introduction and Objective: Type 2 diabetes (T2D) is a heterogeneous disease, with an extensive clinical diversity. While many classifications of T2D have been proposed in recent years, none incorporate inflammatory parameters, despite the critical role of inflammation in the pathogenesis of T2D. In this study, we aim to integrate circulating immune cells (CIC) characterization to […]