Month: July 2025

Introduction and Objective: In individuals with T1D, increased change in CGM (ΔG) is common during physical activity (PA) due to 3 main factors: impaired endogenous glucose production (ΔGegp), increased insulin-dependent glucose utilization (ΔGid), and increased insulin-independent glucose clearance (ΔGii) by skeletal muscles. To understand how the factors affect ΔG during PA, we identify a data-driven […]

Introduction and Objective: Imeglimin, a drug for type 2 diabetes, reportedly promotes β-cell proliferation and β-cell survival; however, the underlying molecular mechanism remains unclear.Methods: We investigated The metabolites in islets after imeglimin treatment via LC-MS.Results: Treatment with imeglimin for one hour significantly altered the levels of 17 metabolites at 5.6 mM glucose and 11 metabolites […]

Introduction and Objective: Type 2 diabetes (T2D), affecting 537 million individuals globally, disproportionately impacts Latin American populations, who experience higher rates of diabetic complications. Despite large-scale genomic studies identifying T2D-associated variants enriched in this population, many lie in non-coding regions, complicating the identification of causal genes. Existing genomics resources like GTEx were developed using data […]

Introduction and Objective: Increasing evidence suggests that stress pathways intrinsic to the β cell contribute to their destruction during type 1 diabetes (T1D) development. Our group has previously shown that loss of sarco-endoplasmic reticulum calcium (Ca2+) pump 2 (SERCA2) exacerbates high-fat diet-induced diabetes in murine models. Here, we assessed whether SERCA2 haploinsufficiency exacerbates loss of […]

Introduction and Objective: Chronic disease behavioral interventions have become widespread across healthcare sectors. While success of these interventions is largely dependent on their implementation, there is an absence of train-the-trainer (TTT) protocols and evaluations to serve as frameworks for behavioral interventions. Therefore, the objective of this study was to develop and evaluate the effectiveness of […]

Introduction and Objective: The high relative free energy of phosphoenolpyruvate (PEP) positions pyruvate kinase (PK) as the driver of insulin secretion in beta-cells by increasing the ATP/ADP ratio and closing KATP channels. In this model, PK depletes ADP for mitochondrial OxPhos, leading to mitochondrial hyperpolarization and OxPhos inhibition. This study explores how PK-driven PEP hydrolysis […]

Introduction and Objective: Although small studies note that PCOS affects up to 1 out of 4 women with T1D, whether this applies to T1D more broadly is unknown. It is also unknown if PCOS confers cardiovascular disease (CVD) risk among youth with T1D, who are already at elevated risk. We examined whether PCOS was associated […]

Introduction and Objective: Current beta cell glucose sensing models require that substrate limited mitochondria can respond to glucose by increasing OxPhos ATP synthesis to close KATP channels (Rutter & Sweet, Diabetes 2024). A primary argument supporting their model is that glyceraldehyde (GA) can increase both respiration and insulin release. Here we test the axiom that […]

Introduction and Objective: Early identification of multi-system involvement in pre-diabetic and diabetic states remains challenging. This study investigated the timing and patterns of concurrent hepatic, bone, and metabolic derangements across different age groups and glycemic states.Methods: Cross-sectional analysis of 591 participants stratified by age (19-40, 41-60, >60 years) and glycemic status (non-diabetic, pre-diabetic, diabetic). Comprehensive […]

Introduction and Objective:Protein S-palmitoylation is a reversible modification involved in the β cell dysfunction that characterizes type 2 diabetes. Palmitate linked to cysteine is removed mostly through the activity of the depalmitoylase acyl-protein thioesterase 1 (APT1), an event important for intracellular trafficking and signaling. APT1 enzyme activity is decreased by hyperglycemia, and mice with islet-specific […]