Month: July 2025

Introduction and Objective: Our previous studies demonstrated that a telehealth-supported Community Health Worker (CHW) intervention significantly improved clinical outcomes in diabetes care. However, the extent to which these benefits vary across different age groups remains unclear.Methods: The aim of this study was to assess the effectiveness of the intervention in changing HbA1c across different age […]

Introduction and Objective: The success of longitudinal studies depends on the retention of participants. We examined sociodemographic, clinical and psychosocial characteristics as predictors of retention among participants with prediabetes and type 2 diabetes (T2D) in the DPP/DPPOS.Methods: 3218 adults who joined the DPP (1996-1999, mean age 51±10y) at high risk of T2D were randomized to […]

Introduction and Objective: CD40 promotes autoimmune inflammation. Current therapeutic approaches are monoclonal antibodies. We designed a 15-amino acid peptide targeting the CD40 receptor.Methods: We treated autoimmune canine diabetes mellitus (CDM) and human T1DM subjects with the peptide. CDM were treated with 2 mg/kg by IV or subcutaneous injection (Sub-Q) for up to 18 months. A […]

Introduction and Objective: We aimed to characterize the long-term changes using body mass index (BMI) time in target range (TTR) and test its independent association with all-cause and cardiovascular mortality.Methods: This study included 3524 patients (58% men) aged 40-80 years with at least 3 BMI measurements within 4 years since their first inpatient diagnosis of […]

Introduction and Objective: Insulin gene (INS) variants are a rare cause of monogenic diabetes, with clinical presentations including (1) permanent or transient neonatal diabetes and (2) adolescent or adult-onset diabetes sometimes referred to as maturity onset diabetes of the young (INS-MODY/MODY10). Here we report four previously undescribed INS variants in individuals with atypical adult-onset diabetes.Methods: […]

Introduction and Objective: The oral glucose tolerance test (OGTT) is ‘gold standard’ for defining carbohydrate metabolism abnormalities. Continuous Glucose Monitoring (CGM) is routinely used in diabetes patients for control assessment and dose adjustment but its role for assessment of prediabetes state is still not clear.The objective of our study is to assess the correlation between […]

Introduction and Objective: Short chain fatty acids (SCFAs) are associated with adverse metabolic outcomes; however, little is known about their link to metabolic disease. Emerging evidence suggests that in addition to acting as signaling molecules, SCFAs also impact cellular metabolism via their conversion to acyl-CoAs by short chain acyl-CoA synthetase (ACSS) enzymes. ACSS3 is a […]

Introduction and Objective: Type 2 diabetes (T2D) may be associated with higher cancer risk through chronic inflammation, insulin resistance, and obesity. We assessed cancer risks across T2D subtypes.Methods: Newly diagnosed T2D (n = 727,076; age: 64.4 years [SD:13.3], 52% female) over 2012-2023 from the Epic Cosmos platform were classified into Severe Insulin-Deficient Diabetes (SIDD, 21.6%), […]

Introduction and Objective: Identifying predictors of postprandial glycemic response variability is critical to advance precision medicine for metabolic diseases. We evaluated whether polygenic scores for macronutrient preference influence postprandial responses to mixed-meals in a clinical setting.Methods: We performed a recall-by-genotype study in 22 adults (21-65 yrs; 54% female) without obesity or metabolic disease, recruited based […]