Introduction and Objective: The oral glucose tolerance test (OGTT) is ‘gold standard’ for defining carbohydrate metabolism abnormalities. Continuous Glucose Monitoring (CGM) is routinely used in diabetes patients for control assessment and dose adjustment but its role for assessment of prediabetes state is still not clear.The objective of our study is to assess the correlation between results from OGTT and data from CGM in patients with observation for prediabetes and to elucidate the usefulness of CGM in these cases.Methods: 109 patients (57 women, 52 men, mean age 40.01±8.87years) with increased risk for diabetes performed monitoring of blood glucose by using DexcomONE for ten days. At the end of this period, they underwent OGTT. Mean weight was 89.07±12.73kg, mean BMI was 32.86±2.0kg/sq.m. and mean HbA1c 5.58±0.38%.Results: Based on OGTT, 7 patients were diagnosed with diabetes and were excluded from data assessment. 75 patients were with normal fasting and 120th minute glucose. In patients with diagnosed impaired glucose tolerance or with increased fasting glucose, CGM showed increased time above the set range (TAR) of 7.8 mmol/l and e area above the curve (phi=0.78, p<0.05). Comparing the CGM data of patients with diagnosed normal carbohydrate state based on OGTT, showed that in 20% (15 patients) there was higher TAR (>5.0%) and AUC above 7.8 mmol/l and the profile was similar to CGM data of patients with diagnosed prediabetesConclusion: OGTT is omitting approximately 20 % of case with changes in glucose profile and gives false negative results, leading to missing on time recommendation to this patients for life changes. CGM gives more precise results in assessing carbohydrate state.
T. Totomirova: None. M. Arnaudova: None.
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