Month: July 2025

Introduction and Objective: Efforts to improve influenza vaccination rates among patients with diabetes can be enhanced with accurate documentation of vaccination status in the electronic medical record (EMR). This quality improvement project aimed to identify factors contributing to inaccurate vaccination status in the EMR documentation.Methods: Ambulatory patients with diabetes presenting for routine follow up were […]

Introduction and Objective: Exendin-4 (Ex-4) is a glucagon-like peptide-1 receptor agonist used for the treatment of type 2 diabetes and other metabolic disorders, including steatotic liver disease. However, its short half-life necessitates multiple daily injections, resulting in poor patient compliance, limited efficacy, and increased treatment costs. To address this problem, we introduce a novel drug […]

Introduction and Objective: Introduction & Objective: Small fiber neuropathy (SFN) is known to develop early in the course of diabetic polyneuropathy (DPN). It has been shown that single nucleotide polymorphisms (SNPs) are involved in DPN, but how SNPs correlate with SFN has not yet been investigated. In the present study, we explored the correlation in […]

Introduction and Objective: Hypercaloric nutrition may sequentially promote insulin resistance across tissues. Recent rodent studies indicate white adipose tissue (WAT) as key driver of whole-body insulin resistance. Thus, we hypothesized that WAT may respond early to overnutrition-induced metabolic changes in humans.Methods: In a randomized, parallel-group study, young glucose tolerant volunteers consumed either an isocaloric (ID; […]

Introduction and Objective: Painful diabetic neuropathy (DN) is a common and challenging complication of diabetes with limited treatments. Our research reveals that treatment responders show enhanced connectivity between the insula and corticolimbic systems, modulated by dopamine and opioid receptors. These findings highlight potential mechanisms of treatment efficacy and pathways for novel therapeutic development.Methods: 43 participants […]

Introduction and Objective: PAQR4, an orphan receptor within the progestin and adipoQ receptor family (PAQR1-11), is implicated in multiple cancers, including hepatocellular carcinoma (HCC). However, its metabolic function in hepatocytes remains unclear. Our recent findings identify PAQR4 as a key regulator of ceramide metabolism. In adipocytes, PAQR4 overactivation leads to ceramide accumulation, disrupting adipose tissue […]

Introduction and Objective: To characterize continuous glucose monitoring (CGM) data in patients with type 2 diabetes (T2D), and to assess the relationship between CGM-derived indicators and diabetes-related clinical parameters.Methods: The data was collected from a randomized trial in China (ChiCTR2000039424), in which patients with T2D wore CGM and received acarbose or sitagliptin. Ordinary least square […]

Introduction and Objective: DA-1241, a novel G protein-coupled receptor 119 agonist, recently completed a Phase 2a clinical trial in presumed metabolic dysfunction-associated steatohepatitis (MASH) patients. This study extended previous findings on its hepatoprotective synergy with glucagon-like peptide-1-based drugs and evaluated its anti-MASH effects in combination with a fibroblast growth factor 21 analogue.Methods: Male C57BL/6JRj mice […]

Introduction and Objective: Dementia, an emerging complication of type 2 diabetes (T2D), may be driven by chronic hyperglycemia and insulin resistance. We evaluated the risk of dementia across T2D subtypes, which differ in clinical profiles and risk of vascular complications.Methods: We identified newly diagnosed T2D (n = 727,076; age: 64.4 years [SD:13.3], 52% female) over […]

Introduction and Objective: An increasing number of individuals with normal weight are attempting weight loss through caloric restriction. However, most weight loss attempts are followed by weight regain, leading to weight cycling. Whether weight cycling poses metabolic risks, especially in normal-weight individuals, remains debated. This study aims to evaluate the effects of weight cycling on […]