Month: July 2025

Introduction and Objective: The choroid plexus (ChP), located in each ventricle of the brain, is recognized as a potential site for leptin transport via short- and long-form leptin receptor (LepR). However, knowledge of how LepR in the ChP regulates leptin transport and energy metabolism remains limited. We investigated the role of LepR in Foxj1-expressing ChP […]

Introduction and Objective: Vascular inflexibility, impairments in vascular perfusion in the setting of metabolic demand, associated with T2D may contribute to the muscle mitochondrial dysfunction and metabolic inflexibility. Oxidative flux in response to ATP demand is dependent on the intrinsic properties of the skeletal muscle mitochondria, insulin action, and perfusion for the delivery of oxygen […]

Introduction and Objective: Stressful and traumatic life events and chronic stress are associated with rising rates of obesity, yet research in this area is limited. In this analysis we examine the impact of stressful and traumatic events and chronic stress on food choices in an experimental Food Snack Test (FST) under acute stress-, neutral- and […]

Introduction and Objective: Long-term low-protein diets (LPD) have been shown to improve metabolic health and extend lifespan in mice, with potential relevance to humans. However, most studies focus on preventive effects, leaving their therapeutic potential for existing metabolic dysfunction underexplored. Previously, we showed that LPD (5.1% kcal from protein) significantly improved postprandial blood glucose (BG) […]

Introduction and Objective: DJBL is a novel endoscopic duodenal jejunal liner device for obesity, both with and without diabetes. We aimed to assess risks vs benefits of DJBL.Methods: In 2017 an independent online registry was established by the Association of British Clinical Diabetologists, to collect of safety and efficacy data worldwide.Results: As of January 2025, […]

Introduction and Objective: We introduce a heavy water (2H2 O) labeling technique to measure fluxes across a metabolome. The principle is that metabolic pathways comprise enzymatic reactions that exchange hydrogen between solvent water and covalent C-H bonds.Methods: The number (n) of exchangeable C-H sites is calculated from combinatorial probabilities (isotope ratios) after 2H2 O labeling, […]

Introduction and Objective: The SECURE-T2D pivotal trial recently demonstrated safety and efficacy of the Omnipod® 5 Automated Insulin Delivery (AID) System in adults with insulin-treated T2D. This sub-analysis evaluated outcomes in participants previously using basal without bolus insulin.Methods: This multicenter 305-participant single-arm trial enrolled 63 participants with T2D using basal without bolus insulin (mean age […]

Introduction and Objective: Asian Indians have increased insulin resistance, more rapid β-cell decline & higher T2D risk. Early interventions targeting these factors can prevent T2D. We compared the effects of a low carbohydrate, low saturated fat (LC) diet to a high unrefined carbohydrate, low fat (HC) diet on β-cell function, insulin sensitivity & fat distribution […]

Introduction and Objective: Bone fragility is a recognized complication of T1D, with previous studies reporting conflicting associations with glycemia. We aimed to evaluate BMD and to identify factors associated with BMD in youth with T1D.Methods: This cross-sectional analysis included youth aged 8-17 years with T1D for ≥1 years. Total body less head (TBLH) BMD was […]

Introduction and Objective: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic liver disease linked to obesity and metabolic disorders. Caloric restriction (CR) and intermittent fasting (IF) improve metabolic health, but their effects on MAFLD and underlying mechanisms are unclear. This study compared CR and IF regimens in MAFLD models and explored the role […]