Month: July 2025

Introduction and Objective: Characterize breadth of benefits, relationships among changes, and processes of change in Community-Based Peer Support (CPS).Methods: CPS was implemented over 24 months in 12 communities (n=1,018) with 4 Comparison Communities (Comp, n=423) in Shanghai, China. CPS participants were = 59.9% female vs 53.5% among Comp, older (mean 66.64 vs 62.94 years), and […]

Introduction and Objective: The present study aimed to investigate the hepatoprotective effects of OPK-88006, a novel GLP-1/glucagon receptor agonist, in the GAN diet-induced obese and biopsy-confirmed mouse model of MASH with liver fibrosis. The late-stage clinical candidates semaglutide and survodutide for the treatment of patients with MASH and liver fibrosis, were included for comparison.Methods: Male […]

Introduction and Objective: Islet endocrine cells rely on efficient prohormone synthesis and elimination of misfolded peptides for proper function. We recently found that endoplasmic reticulum-associated degradation (ERAD) and autophagy are essential protein quality control systems that maintain α cell identity, ER homeostasis, and glucagon (Gcg) production.Methods: To investigate whether ERAD and autophagy serve overlapping roles […]

Introduction and Objective: Metabolic dysfunction-associated steatohepatitis (MASH), a critical stage in NAFLD progression, lacks effective treatments. While GIP/GLP-1R dual agonists (GIP/GLP-1RA) show therapeutic potential, their mechanisms remain unclear. Our preclinical study identified serum BHMT downregulation by GIP/GLP-1RA. This study investigates the BHMT-incretin relationship, its roles in MASH pathogenesis, and its potential as a therapeutic target […]

Introduction and Objective: Understanding the relationship between diabetes, sarcopenia, and lifestyle factors like diet and physical activity remains limited, particularly in the MENA region. While most research focuses on individual nutrients, a dietary pattern approach offers a more comprehensive perspective. This study examines the impact of dietary patterns and diabetes on sarcopenia risk among adults […]

Introduction and Objective: T2D evolves through progressive loss of β-cell secretory capacity and insulin reserve. Non-invasive detection of insulin depletion in β-cells has not been possible. We tested a flux-based method for identifying reduced β-cell insulin stores non-invasively. The time for newly synthesized Ins and C-P to appear and become fully labeled in plasma reveals […]

Introduction and Objective: Automated insulin delivery (AID) is expected to reduce the burden of hypoglycemia including fear of hypoglycemia (FOH) in type 1 diabetes (T1D). This study aimed to evaluate the change in hypoglycemia fear survey-II (HFS-II) scores and hypoglycemia frequency after AID initiation in usual-living conditions.Methods: Adults (≥18years) living with T1D from the Canadian […]

Introduction and Objective: We asked whether insulin (Ins) and C-peptide (C-P) kinetics (β-cell residence times [RT}} measured from islets vs plasma correlate closelyMethods:2H2 O was given for 3 – 18 hr to 32 female ZDF rats fed high fat diet (to induce T2D) or chow. RT of Ins and C-P were measured by high-resolution mass […]

Introduction and Objective: Sulfonylureas (SU), commonly used for type 2 diabetes, are metabolized by liver cytochrome P450 2C9 (CYP 2C9), which is inhibited by amiodarone. Given their frequent co-administration in patients with diabetes and arrhythmia, we evaluated the risk of severe hypoglycemia associated with their concomitant use.Methods: Using South Korean health insurance claims data (2010-2022), […]