Category: Diabetes

Large-scale multiancestry genome-wide association studies have identified hundreds of loci associated with type 2 diabetes (T2D) and glycemic traits, yet imputed genotyping arrays limit the detection of low-frequency and rare variants. Whole-genome sequencing (WGS) offers a more complete view of genetic variation, especially across diverse populations. We analyzed high-coverage (38×) WGS data from 21,913 T2D […]

Type 2 diabetes (T2D) impairs antiviral immunity; however, the causal link between T2D and interferon-α2 (IFN-α2) deficiency remains unclear. This study used genome-wide association study–based Mendelian randomization (MR) to investigate this relationship and validated the findings in an H1N1-infected diabetic mouse model. MR analysis of 26 single nucleotide polymorphisms showed a significant negative association between […]

Home to the headwaters of nine rivers, Algonquin Provincial Park contains thousands of lakes and hundreds of miles of streams, waterways that historically have played a crucial role in Ontario’s lumber industry. During her second year of undergraduate studies at the University of Western Ontario, Erin Mulvihill did a research project sampling benthic invertebrates, the […]

At the request of the University of Oklahoma Health Campus, the above-cited article has been retracted by the American Diabetes Association (ADA), the publisher of Diabetes, to correct the research record due to unreliable data. Source link

Statement of Retraction. Shuangxi Wang, Jian Xu, Ping Song, Benoit Viollet, and Ming-Hui Zou. In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I. Diabetes 2009;58:1893–1901. DOI: 10.2337/db09-0267 . PMID: 19528375. PMCID: PMC2712774 Source link

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