Category: Diabetes

Introduction and Objective: Prior studies identified 5 novel subgroups of type 2 diabetes (T2D) that may predict diabetes-related outcomes. However, these studies utilized laboratory measurements that are not part of a routine T2D visit limiting use in clinical care. Given the increasing prevalence of T2D in young adults (age <45 yrs), our goal was to […]

Introduction and Objective: Pregnancy changes maternal digestion and onset of insulin action. Continuous glucose monitoring (CGM) offers an opportunity to better understand the impact of meal content on postprandial glucose levels in pregnant people with diabetes.Methods: This sub-analysis of 18 participants in the Dexcom G7 pregnancy accuracy trial analyzed 2 hour postprandial CGM data from […]

Introduction and Objective: Compared to people without type 1 diabetes (T1D), those with T1D are at increased risk of mood disorders and sleep difficulties. Partner support is overlooked when assessing these factors in older adults with T1D. We aimed to evaluate whether a sleep companion (SC) influences depression, anxiety, and sleep in the Joslin Medalists […]

Introduction and Objective: Intrauterine exposure to Type 2 Diabetes Mellitus (T2DM) has been associated with an increased risk of cardio-metabolic disorders in offspring, potentially driven by epigenetic modifications primarily DNA methylation. This study aims to investigate the DNA methylation profiles of placental tissues from women with T2DM pregnancies compared to those from normoglycemic (NG) pregnancies.Methods: […]

Introduction and Objective: Evidence suggests that the autonomy supportive intervention, the guided self-determination method (GSD), may reduce diabetes distress in people with type 1 diabetes. The objective was to determine the benefits and harms of a GSD intervention versus an attention control group in adults with type 2 diabetes.Methods: The design was a pragmatic, dual-centre, […]

Introduction and Objective: Maternal caregivers of adolescents with type 1 diabetes (T1D) experience elevated levels of depressive symptoms and diabetes distress, which are established risk factors for poor psychosocial and glycemic outcomes in adolescents. We evaluated the effects of a cognitive behavioral intervention for distressed caregivers in a randomized controlled trial.Methods: Maternal caregivers of adolescents […]

Introduction and Objective: Fee-for-service healthcare makes it difficult for people with T1D to access the care, education, and support that they need. Blue Circle Health (BCH) is a program that closes this gap. BCH is delivered remotely, is 6 months long, and includes coordinated services of endocrinology, peer support, diabetes counseling, case management, insurance navigation, […]

Introduction and Objective: Interstitial glucose concentrations are gaining clinical relevance with advances in CGM, as they more closely reflect glucopenia in cerebral and cardiac tissues. We therefore studied interstitial vs. arterialized-venous (AV) glucose differences during hypoglycemia.Methods: Participants with T2D underwent hyperinsulinemic-hypoglycemic clamps (YSI glucose 2.5 mmol/L [45 mg/dL] for 60 minutes). Interstitial glucose (Dexcom G6, […]

Introduction and Objective: Housing insecurity is an upstream social determinant of the health factors associated with poor health outcomes. Among adults with diabetes, there is little evidence of an association between housing insecurity and glycemic control. Therefore, a secondary data analysis was conducted to assess the association between housing insecurity and hemoglobin A1C (HbA1C) among […]

Introduction and Objective: Adjunct-to-insulin metformin, Glucagon-Like Peptide-1 receptor agonists (GLP1-RA), and Sodium Glucose Co-transporter 2 inhibitors (SGLT2i), mostly off-label, are used by people with type 1 diabetes (PwT1D) to address the challenges of glucose control and other outcomes. We investigated the socio-demographic and disease-related characteristics associated with their use.Methods: Cross-sectional comparison of self-reported demographic and […]