Category: Diabetes

Introduction and Objective: Diabetes distress, the emotional and behavioral challenges of living with type 1 diabetes (T1D), is common over the lifespan and can lead to adverse medical and psychological outcomes. Interventions that incorporate stakeholder input on diabetes distress across the lifespan remain limited. The ReDUCe Study aims to reduce diabetes distress in adults with […]

Introduction and Objective:GLP1R R131Q (rs3765467) has been reported as a type 2 diabetes protective variant in genome-wide association studies and glucagon-like peptide-1 receptor (GLP1R) activation has been shown to have various β cell protective effects. We hypothesized that the variant induces a gain-of-function change enhancing the β cell protective effects mediated by GLP1R activation.Methods: We […]

Introduction and Objective: Prior research has shown a link between marital quality and HbA1c in adults with T1D, however, little is known about how parenting impacts glycemic control, including CGM metrics. The aim of the current study was to investigate whether relationship and parenting status impact glycemic outcomes in adults with T1D. Emotional distress was […]

Introduction and Objective: ASC47 (selective THR-β agonist) is an adipose-targeted, once-monthly subcutaneously (SQ) injected, muscle-preserving weight loss drug candidate for the treatment of obesity, discovered and developed in-house at Ascletis. This study in diet-induced obese (DIO) mice demonstrated a powerful synergy in weight loss and muscle preservation when combining ASC47 and semaglutide.Methods: C57BL/6J mice were […]

Introduction and Objective: Private integrated healthcare and public safety-net care systems address the medical needs of different socioeconomic (SES) status groups. Irrespective of SES, many young adults with T1D struggle with diabetes management. The study evaluated survey data of Black young adults with T1D in two different healthcare systems to understand psychosocial factors, diabetes care […]

Introduction and Objective: There have been growing concerns about GLP-1 RA use and the risk of aspiration pneumonia. Mixed results exist regarding aspiration pneumonia risk with perioperative GLP-1 RA use, with limited focus on elective surgical procedures. Therefore, we assessed the association between preoperative GLP-1 RA use and postoperative respiratory complications in patients undergoing elective […]

Introduction and Objective: Prediabetes (preDM) among adults is on the rise, physical activity (PA) and healthy diet as modifiable lifestyle influencing factors can help prevent or delay progression to type 2 diabetes in adults with preDM, but it is unclear whether these factors vary by prediabetic status.Methods: Cross-sectional study of Chines adults without DM who […]

Introduction and Objective: We asked how a diabetes distress (DD) intervention fostered changes in diabetes-related emotion management, diabetes problem solving, and HbA1C; and to test a hypothesized 4-Stage, sequential pathway whereby reductions in DD were linked with improved glycemic outcomes.Methods: PWDs with T1D (n=276) with elevated DD and HbA1cwere assigned to: StreamLine, a diabetes self-management […]

Introduction and Objective: Digital health can improve outcomes for people with type 2 diabetes (T2D). Use of digital health tools, however, vary across patient populations. How health related social needs (HRSN) impact digital health use is largely unknown.Methods: Data from the 2022 Health Information National Trends Survey were analyzed to investigate the association between HRSN […]

Introduction and Objective: To amplify insulin secretion from beta cells with nutrient-stimulated hormone (NuSH) receptor agonists (e.g., the GLP-1 RA liraglutide (LIRA)), mitochondria must be energized via substrate-driven ADP privation. Since small-molecule modulators of Pyruvate Kinase (mPK) energize mitochondria via the phosphoenolpyruvate cycle and further boost LIRA-amplified insulin secretion, we hypothesized that mPKs could also […]