Category: Diabetes

Introduction and Objective: Electronic cigarettes (e-cigs) have become the main tobacco product used by youth. Although the effects of conventional cigarette use have been studied, the metabolic effects of e-cigs have yet to be explored. In mice on a high-fat diet (HFD), we have shown that e-cig treatment produces cardiac dysfunction in a lipolysis-dependent manner. […]

Introduction and Objective: Obesity and type 2 diabetes are strongly associated with accelerated cognitive decline. We tested whether chronic high-fat diet (HFD) feeding with sucrose intake impairs cognition in mice and whether TLC-1180, a novel mitochondrial protonophore, improves metabolic and neural deficits.Methods: Male C57BL/6J mice were fed regular chow (RC) or HFD with 1% sucrose […]

Introduction and Objective: Oral, small-molecule GLP-1RA receptor agonists hold significant promise to provide durable weight loss and improved long-term outcomes for those living with obesity, Type 2 diabetes or other chronic cardiometabolic disorders. The objective of this research was to demonstrate the differentiated profile of the oral GLP-1 receptor agonist and development candidate, AMB-702, with […]

Introduction and Objective: Amylin is an attractive target for obesity therapy. Eloralintide is a selective and potent once-weekly subcutaneously administered amylin analog peptide, which has demonstrated promising efficacy and safety profile in a 48-week clinical trial for obesity. ASC39 is a novel oral small molecule amylin receptor agonist development candidate. This study evaluates in vitro […]

Introduction and Objective: Uncoupling protein 1 (Ucp1) activation drives potent adipose thermogenesis, yet the target is widely considered undruggable by conventional therapeutic modalities. Targeting the Ucp1 promoter with small activating RNA (saRNA) offers a novel RNA activation (RNAa) approach to overcome this barrier. We evaluated the efficacy, body composition, and durability effects of LiCO-saUcp1—an adipose-biased, […]

Introduction and Objective: Lifestyle behaviors (LB) have gained widespread acceptance as a key component of diabetes management since first featured in the 2017 ADA Standard of Care, with emphasis on modifiable LB and practical screening tools to optimize diabetes prevention and management. However, clinical application of existing screening measures remains limited by their length and […]

Introduction and Objective: Ask the Experts (EXPERTS) supports U.S. individuals who screen positive for type 1 diabetes islet autoantibodies (IA) and their health care providers (HCPs). Because clinical capacity to monitor and counsel patients with early-stage type 1 diabetes remains limited, we piloted a 1-day CME-accredited mini-fellowship to build HCP confidence and capacity for early-stage […]

Introduction and Objective: Multimorbidity is common in diabetes and may impact cognitive risk. We used latent class analysis to identify multimorbidity phenotypes and their association with incident dementia.Methods: We included 28,043 adults with diabetes. Twenty-two comorbidity indicators were used to identify multimorbidity classes. We fitted Cox models adjusted for sociodemographic and clinical variables.Results: The incidence […]

Introduction and Objective: The CBeyond trial is an ongoing Phase 2a study evaluating nimacimab, a peripherally restricted anti-CB1R inverse agonist mAb, on weight loss. Nimacimab monotherapy, (sc 200 mg QW), is compared to placebo and nimacimab plus semaglutide to semaglutide alone over 26 weeks of treatment, followed by 12 weeks of follow-up off therapy or […]

Introduction and Objective: Nutrition and lifestyle interventions are central to diabetes management, and studies have demonstrated their effectiveness in improving diabetes outcomes. This review aimed at identifying intervention components, delivery settings, and durations that are likely to produce improved clinical outcomes for diabetes individualsMethods: A comprehensive literature search was conducted across 5 electronic databases (MEDLINE, […]