Introduction and Objective: Elderly individuals with diabetes are less likely to be offered continuous glucose monitoring (CGM), as they are often perceived as having difficulties using this technology. We conducted a retrospective observational study to assess the use of CGM in patients with diabetes aged ≥70 years.Methods: Patients aged ≥70 years with diabetes treated with […]
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2287-P: Trends and Disparities in Mortality Due to Coexisting Diabetes Mellitus and Chronic Obstructive Pulmonary Disease among Adults in the U.S. (1999–2023): Insights from the CDC Wonder Database
Introduction and Objective: The coexistence of diabetes and chronic obstructive pulmonary disease (DM and COPD) portends poorer outcomes. Yet, nationwide mortality trends and geographic disparities for this comorbidity are poorly characterized.Methods: We analyzed CDC WONDER Multiple Cause-of-Death data (1999-2023) for adults ≥35 with both DM and COPD. Age-adjusted mortality rates (AAMRs per 100,000) were calculated. […]
Read More2694-LB: Primary and Endocrinology Care for Adults with Diabetes following Hyperglycemic and Hypoglycemic Crises in Rural and Urban Areas
Introduction and Objective: To explore rural-urban differences in follow-up in primary and endocrinology care among adults with diabetes who experienced hyperglycemic or hypoglycemic crises requiring emergency department (ED) or hospital care.Methods: This is a retrospective cohort study leveraging electronic health record data from a large integrated healthcare delivery system in the U.S. Upper Midwest between […]
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Food coloring additives & T2D, automated insulin delivery systems in T2D, and more!
Welcome to the latest episode (June 2026) of Diabetes Core Update, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month on DOC Update: Shah S, et al. “Food Coloring Additives and Incidence of Type 2 Diabetes in the NutriNet-Santé Prospective Cohort […]
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Special Edition: Obesity Processes and PATHWEIGH for Obesity Care
In this special edition of Diabetes Core Update, Neil Skolnik discusses PATHWEIGH, a novel obesity care process for primary care clinicians which has demonstrated a decrease in population weight gain. This special episode is sponsored with support from Lilly. Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas […]
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Special Edition: Obesity—The Changing Landscape
In the first episode of this series on Obesity, our host is joined by Dr. Mikhail Kosiborod to discuss the evolving science and cardiometabolic diseases associated with obesity. This special episode is sponsored with support from AstraZeneca. Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; […]
Read MoreInterrupting T-Cell Memory Ameliorates Exaggerated Metabolic Response to Weight Cycling
Weight cycling has been demonstrated, in humans and animal models, to increase cardiometabolic disease and disrupt glucose homeostasis. Both obesity itself and weight cycling cause adipose tissue inflammation and metabolic dysfunction. Studies show that even after weight loss, increased numbers of lipid-associated macrophages and memory T cells persist in adipose tissue and become more inflammatory […]
Read MoreUnraveling Diabetic Cardiomyopathy (DCM): The Critical Role of the Yap–miR-22-3p–Sirt1 Axis in the Pathogenesis of DCM
Diabetic cardiomyopathy (DCM), characterized by myocardial hypertrophy and fibrosis, is a severe complication of diabetes. Activation of Yes-associated protein (Yap) has been implicated in myocardial remodeling and cardiac dysfunction. This study aimed to elucidate the role and underlying molecular mechanisms of Yap in DCM. Yap expression was evaluated in mice with type 2 diabetes mellitus […]
Read MoreKetogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome
Metabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health or reversing established PN is less clear. First, in a maintenance paradigm, we […]
Read MorePredicting the Timing of the Metabolic Inflection Point in Type 1 Diabetes Progression Using Machine Learning and Survival Analysis Models
An inflection point (IP) marking accelerated β-cell decline occurs ∼1–2 years before type 1 diabetes diagnosis. Precisely determining this timing could optimize clinical intervention. We developed machine learning models to predict proximity to the inferred metabolic IP using oral glucose tolerance test (OGTT) data from islet autoantibody-positive individuals in the TrialNet Pathway to Prevention study. […]
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