Home to the headwaters of nine rivers, Algonquin Provincial Park contains thousands of lakes and hundreds of miles of streams, waterways that historically have played a crucial role in Ontario’s lumber industry. During her second year of undergraduate studies at the University of Western Ontario, Erin Mulvihill did a research project sampling benthic invertebrates, the […]
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Statement of Retraction. Yunzhou Dong, Miao Zhang, Shuangxi Wang, Bin Liang, Zhengxing Zhao, Chao Liu, Mingyuan Wu, Hyoung Chul Choi, Timothy J. Lyons, and Ming-Hui Zou. Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo. Diabetes 2010;59:1386–1396. DOI: 10.2337/db09-1637 . PMID: 20299472. PMCID: PMC2874699
At the request of the University of Oklahoma Health Campus, the above-cited article has been retracted by the American Diabetes Association (ADA), the publisher of Diabetes, to correct the research record due to unreliable data. Source link
Read MoreStatement of Retraction. Shuangxi Wang, Jian Xu, Ping Song, Benoit Viollet, and Ming-Hui Zou. In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I. Diabetes 2009;58:1893–1901. DOI: 10.2337/db09-0267 . PMID: 19528375. PMCID: PMC2712774
Statement of Retraction. Shuangxi Wang, Jian Xu, Ping Song, Benoit Viollet, and Ming-Hui Zou. In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I. Diabetes 2009;58:1893–1901. DOI: 10.2337/db09-0267 . PMID: 19528375. PMCID: PMC2712774 Source link
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Special Edition: What's Next—Once-Weekly Insulins—Mechanisms and Practical Considerations
Continuing his exploration of once-weekly insulins, Neil Skolnik speaks with Aaron King, MD. Together, they cover the mechanisms, practical considerations, and the myriad benefits that this new therapy can have over daily basal insulin. This special episode is sponsored with support from Novo. Please listen to the episodes by clicking on the podcast player below […]
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Special Edition: What's Next—CKD in Type 1 Diabetes—An Urgent Need for Therapies
There is a fundamental link between diabetes and kidney care. But while there are many medications available to improve CKD outcomes in people with type 2 diabetes, the same options are not available for people with type 1. In this special episode, Dr. Neil Skolnik speaks with Janet McGill, MD, MA, FACE, FACP about the […]
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Efficacy and safety of CagriSema & Retatrutide, CGM benefits beyond T2D, & more!
Welcome to the latest episode (July 2026) of DOC Updates, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month on DOC Updates: Aroda V, Buzzetti R, Dalskov S et al. “Efficacy and safety of once-weekly cagrilintide–semaglutide (CagriSema) in adults with type […]
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Special Edition: Medications in the Pipeline for Cardiometabolic Disease
In this special edition of DOC Updates, Neil Skolnik speaks with Dr. Juan Frias, who catalogues the latest cardiometabolic medications, emphasizing the distinguishing characteristics of each. This special episode is sponsored with support from Lilly. Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, […]
Read MoreSex-Dependent Diabetes Impact of Acute Grp78 Deletion in β-Cells of Adult Mice
GRP78/BiP/HSPA5 is a widely expressed endoplasmic reticulum (ER) chaperone that also performs the critical role of regulating the unfolded protein response, an adaptive mechanism that maintains ER homeostasis. As the exclusive source of circulating insulin, pancreatic β-cells are prone to ER stress due to proinsulin synthesis workload. GRP78 is important for the ER stress response, […]
Read MoreActivating Transcription Factor 6α Governs Stress-Adaptive Pancreatic β-Cell Mass Expansion by Coordinating Proliferation and Survival
Progressive loss of pancreatic β-cell mass (BCM) is a hallmark of type 2 diabetes, yet strategies to preserve or restore BCM remain elusive due to incomplete understanding of the molecular mechanisms governing β-cell proliferation in adults. The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis, but the in vivo role of activating transcription factor 6α […]
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