Category: Diabetes

Fujiwara Memorial Foundation10.13039/100019432Foundation of Future Research SupportJapan Diabetes Foundation10.13039/501100012627Japan Society for the Promotion of Science10.13039/50110000169124K02359Suzuken Memorial Foundation10.13039/100007434Advanced Science, Technology & Management Research Institute of KYOTOJapan Foundation of Applied EnzymologyThe Moriya Scholarship FoundationThe Japan Health FoundationJapan Association for Diabetes Education and Care10.13039/100016573Suzuki Manpei Diabetes Foundation Source link

Type 2 diabetes partitioned polygenic risk scores (pPRS) are related to their physiological impact on insulin secretion and sensitivity. We investigated associations of two pPRS sets obtained from multiancestry cohorts with the relationship between insulin secretion and sensitivity and diabetes incidence in the Diabetes Prevention Program (DPP). We generated 12 and 8 pPRS from soft- […]

Introduction and Objective: College education is consistently associated with lower prevalence of diabetes, yet this protective effect may not operate uniformly across racial groups. Minorities’ Diminished Returns theory posits that education yields smaller health returns for Black people due to structural barriers including employment discrimination, residential segregation, and differential healthcare access.Methods: Using 2024 Behavioral Risk […]

Introduction and Objective: Latent autoimmune diabetes (LADA) may affect between 2-12% of adults with new-onset diabetes mellitus (DM) but is often underdiagnosed. We investigated LADA screening rates among adults with new-onset diabetes within a nationwide U.S. cohort.Methods: Epic Cosmos is a dataset representing over 300 million patients. We determined the rates at which C-peptide levels […]

Introduction and Objective: Pregnant individuals experience progressive shifts in substrate metabolism and insulin resistance to support fetal growth. Although prenatal exercise is recommended to improve maternal metabolic health, the effect of different exercise modes on maternal glycemia and insulin resistance remains unclear. Therefore, the objective was to determine whether exercise mode influences maternal fasting blood […]

Introduction and Objective: Prolonged fasting induces a metabolic switch from glucose to ketone utilization, which may influence cognitive function and metabolic health. However, data on cognitive effects of prolonged fasting (≥24 h), ketone-confirmed metabolic switching, and sex-specific responses remain limited.Methods: In a randomized, within-subject crossover pilot study, healthy adults (18-55 years) completed a control condition […]

Introduction and Objective: Gestational diabetes (GDM) increases future cardiovascular disease (CVD) risk, but the link between gestational glucose intolerance (GGI), subclinical hyperglycemia in pregnancy that does not meet criteria for GDM, and CVD is unclear. We examined the association between GGI and future CVD risk.Methods: This was a single-center, retrospective study (1998-2016) in an electronic […]

Introduction and Objective: Substantial research has demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter 2 inhibitors (SGLT-2i) combination therapy plays an important role in the treatment of type 2 diabetes mellitus (T2DM). Here, we investigated the potential synergistic hypoglycemic effects of HDM1010, which is a combination product of HDM1002 and SGLT-2i in a […]

Introduction and Objective: Maternal fasting triglycerides (FTG), mainly hepatic VLDL TG, are higher in obese pregnancies and rise substantially over gestation under the influence of a 100-fold increase in placental estradiol (EST). Historically this rise was thought to occur in a dose-dependent pattern to support maternal metabolism as glucose is spared for fetal growth. Data […]

Introduction and Objective: IcoSema is a once-weekly combination therapy of insulin icodec + semaglutide. This post hoc analysis assessed CGM-based metrics of IcoSema vs glargine U100 using blinded CGM data from COMBINE 4, a 40-week, phase 3b trial in T2D.Methods: Adults with T2D inadequately controlled on oral glucose-lowering medications were randomized 1:1 to IcoSema or […]