Category: Diabetes

Introduction and Objective: Pancreatic β-cell number increases during pregnancy to compensate for insulin resistance. While this involves β-cell proliferation a transdifferentiation from other islet cell types, such as somatostatin (Sst)-secreting δ-cells, may also occur. It is unclear whether δ-cell mass (DCM) is also increased during pregnancy, the extent to which transdifferentiation contributes to increased β-cell […]

Introduction and Objective: Hypertriglyceridemia may explain higher atherosclerotic cardiovascular disease (ASCVD) risk in women with type 2 diabetes (T2D) than men. We examined the causal relationship between triglycerides (TG) and ASCVD in men (M) and women (W) with T2D.Methods: We included participants with T2D from the Electronic Medical Records and Genomics (eMERGE) Network, who had […]

Introduction and Objective: Late-stage pregnancy induces a physiological shift toward accelerated starvation, characterized by attenuated glucose use, enhanced fatty acid oxidation, and elevated circulating ketones. Ketones cross the placenta and remain key substrates postnatally, with the neonatal brain consuming ~50% of hepatic output to sustain lipid biosynthesis and energy demands. The consequences of supraphysiological ketone […]

Introduction and Objective: In hospitals, point-of-care (POC) glucose checks are often disconnected from meal delivery, delaying prandial insulin beyond the therapeutic window and contributing to poor glycemic control. We evaluated the feasibility of a structured implementation project aimed at reducing POC glucose-to-insulin administration times on an inpatient medical-surgical nursing unit.Methods: Nursing staff underwent brief training […]

Introduction and Objective: Mesenchymal stem cells (MSCs) from infants born to mothers with obesity and diabetes demonstrate increased adipogenic capacity, but the molecular mechanisms underlying this effect are unclear. The objective was to quantify changes in miRNA abundance in MSCs resulting from diabetes exposure and map their potential downstream pathways.Methods: Pregnant persons, 18 control and […]

Introduction and Objective: The AKI-to-CKD transition lacks effective therapies. Cathepsin L (CTSL), a protease involved in renal fibrosis, is a potential target. This study determined whether CTSL inhibition alleviates progression in a murine IR injury model.Methods: 8-week-old male C57BL/6J mice received a CTSL inhibitor (998, 10mg/kg/day) or vehicle by oral gavage, starting 2 days before […]

Introduction and Objective: Disparities in diabetes technology use are now well described in youth with type 1 diabetes, but little is known about the role of medical mistrust and racism in healthcare as it relates to technology use.Methods: Baseline surveys from a larger intervention study with 51 caregivers of Non-Hispanic Black youth with type 1 […]

Introduction and Objective: Adult-onset autoimmune diabetes (AD), driven by immune-mediated β-cell destruction, leads to early failure of oral antidiabetic agents and rapid insulin requirement. Fourlanos et al. (2006) proposed a five-item clinical score (age <50 years, BMI<25 kg/m², personal history of autoimmune disease, family history of autoimmune disease, and acute hyperglycemic symptoms at diagnosis) to […]

Introduction and Objective: Individuals with PDN experience substantial reductions in quality of life due to both pain and loss of sensory function. A multicenter RCT evaluated the effectiveness of 10kHz SCS plus conventional medical management (CMM) versus CMM alone for improving pain and sensory function in people with PDN.Methods: Eligible PDN participants with lower-limb pain […]

Introduction and Objective: This secondary analysis of the GO MOMs cohort evaluated associations of first trimester maternal BMI, CGM, OGTT, HbA1c and metabolic measures with newborn adiposity.Methods: At 9 US centers gravidas with singletons and no pre-existing diabetes underwent 75g OGTT, HbA1c, CGM and fasting lipid measures (free fatty acids-FFA; triglycerides-TG) at 10-14 weeks’ gestation. […]