Category: Diabetes

Introduction and Objective: Tirzepatide, a dual GLP-1 and GIP receptor agonist, enhances glucose-stimulated insulin secretion, significantly reduces HbA1c, and promotes weight loss. Tirzepatide use leads to improvements in insulin sensitivity, both via weight loss-dependent and independent mechanisms. Pioglitazone, a PPARγ activator, enhances insulin sensitivity via distinct pathways. We hypothesized that combining Tirzepatide and pioglitazone would […]

Introduction and Objective: PCSK9 inhibition with evolocumab (evo) decreased CV events in pts at high CV risk w/o a prior MI or stroke in VESALIUS-CV. This pre-specified analysis evaluates the efficacy of evo in pts w/ high-risk diabetes mellitus (HR-DM) for prevention of first CV events.Methods: VESALIUS-CV randomized pts w/ LDL-C ≥90mg/dL and atherosclerosis or […]

Introduction and Objective: To address the unmet need for sustainable lifestyle interventions in type 2 diabetes (T2D), we evaluated the sustained effects of a Teaching Kitchen (TK) program among patients with T2D in Japan.Methods: We conducted a randomized controlled trial with 112 patients (59 men, 53 women) aged 20-79 years with T2D and BMI ≥23 […]

Introduction and Objective: In GO MOMS, a multicenter observational study, % time above range (TAR) >134mg/dL, as determined from early pregnancy CGM, added statistically significant but not clinically meaningful predictive value for GDM compared to clinical factors alone. We sought to assess if prediction models incorporating CGM metrics derived from multiple time points improved GDM […]

Introduction and Objective: Early-stage diabetic retinopathy (DR) is characterized by vascular endothelial cell damage and breakdown of the blood-retinal barrier. We and others previously shown that CysLTR1 antagonist Montelukast (MON) is a promising treatment for diabetes-related eye issues. This study aims to develop and assess the effectiveness of new MON derivatives in alleviating endothelial dysfunction […]

Introduction and Objective: Despite advances in the development of new insulin formulations and the use of diabetes technologies, severe hypoglycemia remains a major problem for people with type 1 diabetes on intensive insulin therapy due in part to defective counterregulatory hormone responses and a lack of symptomatic awareness of hypoglycemia. Elevated brain lactate levels in […]

Introduction and Objective: To achieve adipose mass reduction while maintaining or improving insulin sensitivity involves an integration of multiple neuroendocrine and paracrine inputs that requires an in vivo setting to be adequately studied. We therefore performed in vivo Perturb-Seq of visceral adipocytes to identify novel targets for the treatment of obesity.Methods: An AAV library encoding […]

Introduction and Objective: Type I (IFNα) and Type II (IFNγ) interferons have been shown to play a critical role in T1D pathogenesis. Studies on pancreatic biopsies from individuals with recent-onset T1D suggest an upregulation of IFN-stimulated gene signatures. However, their impact on the β-cell epitranscriptome and translatome remains untested.Methods: Human islets from 12 cadaveric donors […]

Introduction and Objective: T2D is a heterogeneous disease involving defects in multiple metabolic processes, which could be assessed by partitioned pathway-specific polygenic scores (pPS) developed from clustering T2D GWAS lead variants based on associations with related cardiometabolic traits. Here, we demonstrate the use of T2D pPS to identify T2D patient subgroups with distinct clinical features […]

Introduction and Objective: In GO MOMs, early pregnancy OGTT did not sufficiently improve prediction of gestational diabetes (GDM) or large-for-gestational age birthweight (LGA) beyond clinical factors to warrant universal first-trimester screening. This secondary analysis evaluated if early metabolic or lipid measures improved predictions of these outcomes.Methods: Singleton gravidas without preexisting diabetes from 9 US centers […]