Category: Diabetes

Introduction and Objective: While diabetic ketoacidosis (DKA) prediction models have been successfully developed using electronic health record (EHR) data, incorporating continuous glucose monitoring (CGM) metrics may further improve risk stratification. To explore this possibility, we examined the association between CGM metrics and DKA events in adults with type 1 diabetes (T1D).Methods: We identified adults with […]

Introduction and Objective: The protein kinase A (PKA) signaling cascade is the core signaling pathway of hepatic gluconeogenesis. However, the mechanisms governing PKA nuclear translocation remain incompletely understood. In this study, we identified the nuclear membrane protein TMEM201 (transmembrane protein 201) as a critical regulator of PKA nuclear translocation.Methods: PKA catalytic subunits were used as […]

Introduction and Objective: A high intake of dietary fiber has been shown to improve glycemic management in individuals living with Type 2 diabetes (T2D). We developed FiberMore, a generative AI-based mobile app grounded in the Theory of Planned Behavior, to address inadequate fiber intake in individuals with T2D, and assessed its efficacy in increasing fiber […]

Introduction and Objective: Human pluripotent stem cell-derived pancreatic β-like cells (hPSC-β cells) represent a promising cell source for diabetes therapy. However, their clinical translation is hampered by time- and cost-intensive differentiation protocols. Establishing a scalable expansion system for hPSC-derived pancreatic endoderm (progenitor) cells (hPSC-PEs) would enable accessible regenerative therapies.Methods: To identify the mechanisms limiting their […]

Introduction and Objective: Short-term use of a single stand-alone 14-day continuous glucose monitoring (CGM) improves glycemic awareness and self-management in non-insulin-treated (NIT) patients with type 2 diabetes (PwT2D). This study examined whether supplementing short-term CGM use of 9-14 days with access to a digital learning platform or a blended in-person course and webinar enhances self-reported […]

Introduction and Objective: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by chronic immune activation and stromal remodeling; however, the paracrine mechanisms linking parenchymal metabolic stress to immune-stromal responses remain poorly understood. This study aimed to identify key paracrine signals driving inflammatory and fibrogenic remodeling in MASH and to define their downstream mechanisms.Methods: Integrative transcriptomic and secretome […]

Introduction and Objective: Older adults benefit from continuous glucose monitoring (CGM) use, but CGM initiation and sustained use often require intensive educator support, and time requirements are poorly characterized. We quantified educator time and support needs during the REST study.Methods: REST is a prospective 12-month study conducted in older adults (≥65 years) with insulin-treated diabetes, […]

Introduction and Objective: The iCan CGM system is equipped with 3rd generation sensor technology and based on a different enzyme (GDH-FAD) than other FDA approved CGM systems in US. This 15d factory calibrated sensor is available in many regulated markets worldwide and was evaluated in a multi-center study for iCGM compliance in a pediatric sample […]

Introduction and Objective: Type 2 diabetes (T2D) is associated with elevated cancer risk, yet whether heterogeneity in T2D identifies individuals at particularly high or low risk relative to individuals without diabetes remains unclear. We evaluated site-specific cancer risk across T2D subtypes compared with adults without diabetes.Methods: We analyzed retrospective electronic health records from Epic Cosmos […]

Introduction and Objective: Despite recent improvements in generating functional human insulin-producing β cells, stem cell-derived beta-like cells (sBC) still develop and function less efficiently than bona fide β cells from cadaveric islets. Therefore, we sought to identify key factors affecting efficient sBC generation during differentiation, with a focus on reducing time for sBC generation while […]