Category: Diabetes

Introduction and Objective: Innate immune signaling is a key driver of diabetic nephropathy (DN). We previously showed that diabetes-induced expression of the stress protein REDD1 contributes to proinflammatory signaling in podocytes. The objective of this study was to determine if therapeutic suppression of REDD1 in podocytes was sufficient to mitigate renal inflammation in diabetic mice.Methods: […]

Introduction and Objective: Calcium is a key regulator of insulin secretion; yet, regulation of mitochondrial calcium handling is understudied in pancreatic β-cells. Here, we assessed whether mitochondrial calcium (mtCa2+) overload by deletion of the mitochondrial sodium-calcium exchanger (NCLX) in β-cells is sufficient to perturb glucose homeostasis in vivo. Given that mitochondrial metabolic activity is calcium-dependent, […]

Introduction and Objective: GDF8 and activin A signal through the activin typeII receptor ActRIIA and ActRIIB to limit muscle growth. However, the specific role of each ActRII at regulating muscle mass remains to be elucidated. Here we pharmacologically interrogate the function of ActRIIA and ActRIIB using human myoblast differentiation model which is highly predictive of […]

Introduction and Objective: Immune-mediated rejection remains a major barrier to durable pancreatic islet transplantation for type 1 diabetes. Mesenchymal stromal/stem cells (MSCs) possess immunomodulatory properties, and engineering MSCs to overexpress alpha-1 antitrypsin (AAT) may enhance their therapeutic potential. This study evaluated whether co-transplantation of human islets with AAT-overexpressing MSCs (AAT-MSCs) improves graft survival and modulates […]

Introduction and Objective: T1D-CATCH (Collaboration Around Technology using Community Health Workers) was a hybrid effectiveness-implementation randomized trial evaluating a 6-month CHW intervention to increase diabetes technology use among high-risk young adults with T1D. Co-designed with young adults and providers, the intervention aimed to reduce provider burden and deliver patient-centered technology support. This report focuses on […]

Introduction and Objective: Excessive diabetes device alerts can be burdensome for people with diabetes. Frequent autocorrection boluses inherent to the MiniMed™ 780G (MM780G) system are shown to reduce nighttime (SG) alarms/alerts.1 The present study assessed SG alarm/alert burden and glycemia in system users with and without optional SG alerts on.Methods: Deidentified CareLink™ data (01FEB2025 to […]

Introduction and Objective: Skeletal muscle plays a central role in whole-body lipid metabolism through mitochondrial and peroxisomal fatty acid oxidation (FAO). When skeletal muscle lipid metabolism is impaired, whole-body adaptations occur to maintain metabolic homeostasis. We hypothesized that limiting skeletal muscle lipid metabolism through mitochondria &/or peroxisomes would trigger adaptive responses to reduce dietary lipid […]

Introduction and Objective: RNA modifications are crucial regulators of gene expression in human development. They have an established role in regulating β cell development and function, with dysregulation resulting in diabetes. Numerous limitations have restricted the study of these modifications directly in pancreatic tissue. We utilize a cohort of human fetal pancreatic samples to determine […]

Introduction and Objective: Despite its systemic impact, MASLD is often overlooked in routine T2DM care. Our study evaluates whether glycemic status and the NFS are associated with the prevalence and severity of microvascular complications in hospitalized patients with T2DM.Methods: Our retrospective cross-sectional study analyzed data from 4,009 hospitalized patients with T2DM in Almaty, Kazakhstan (2017-2019). […]

Introduction and Objective: Recurrent insulin-induced hypoglycemia blunts the counterregulatory response (CRR) to hypoglycemia. Since antecedent hyperinsulinemia coincides with antecedent hypoglycemia, it is possible that recurrent insulin administration per se could contribute to the pathophysiology of a blunted CRR. To target insulin delivery to the central nervous system, this study tested the hypothesis that recurrent intranasal […]