Category: Diabetes

Introduction and Objective: Up to 30% of youth with type 1 diabetes (T1D) report elevated depressive symptoms, which negatively impact T1D management. Behavioral health interventions exist to improve mood and promote treatment engagement, but their high cost and long duration are implementation barriers. Further, <25% of youth with T1D referred for mental health services attend […]

Introduction and Objective: Patients with diabetes and intellectual, developmental, and physical disabilities (IDPD) often have worse glycemic control and greater complications but may be overlooked when prescribing diabetes technology. This project aimed to increase insulin technology prescriptions at an academic center by 15% in patients with diabetes and IDPD over one year using a physician […]

Introduction and Objective: Adipose tissue insulin resistance(IR) is related with metabolic disorders. However, evidence regarding sex differences in adipose IR remains limited. This study aimed to identify factors associated with adipose IR and to examine sex differences and their potential modifiers.Methods: This cross-sectional study included 9,935 adults undergoing routine physical examinations. Adipose IR index(Adipo-IR) was […]

Introduction and Objective: Adults with T2D not treated with insulin face distinct and ongoing self-management challenges. This qualitative study explored how CGM versus routine care (RC, without CGM) impacts psychological, behavioral, and emotional outcomes in this population.Methods: Semi-structured interviews were conducted virtually with a randomly selected subset of participants from the CONNECT randomized trial at […]

Introduction and Objective: In type 2 diabetes mellitus (T2DM) with atherosclerosis, high-density lipoprotein cholesterol (HDL-C) levels may appear normal, but may exhibit reduced functionality. ATP-binding cassette transporters play a crucial role in HDL functionality, but there are only a few clinical studies. We evaluated the levels of ABC transporters (ABCA1 and ABCG1) in T2DM compared […]

Introduction and Objective: A real-world assessment of the 1-year implantable Eversense 365 CGM System was conducted in adults with diabetes using open-loop insulin regimens.Methods: Anonymized sensor glucose (SG) data from the Eversense Data Management System (DMS) for the first 8277 sensors in the US were used to compare glucometrics from the 1st and 2nd 6-months […]

Introduction and Objective: Obesity associated with type 2 diabetes (T2DM) is known to cause white adipose tissue hyperplasia associated with oxidative stress. Stem/ progenitor cell therapy may provide a novel strategy for treating obesity- and diabetes-related complications. Our laboratory has shown success in using p53-silenced endothelial progenitor cells (EPCs) in disease models such as hyperglycemia-associated […]

Introduction and Objective: Gestational diabetes mellitus (GDM) increases the risk of early-onset prediabetes (<40 years). We hypothesized that biological pathways mediating the transition from pregnancy to early-onset prediabetes one year postpartum differ between women with prior GDM and those with normoglycemic (NG) pregnancies, using stratified longitudinal analyses with deep metabolic phenotyping.Methods: In the prospective, multicenter […]

Introduction and Objective: The natural history of type 2 diabetes (T2D) is characterized by a gradual decrease of insulin sensitivity and characteristically a steep decline of beta cell function short before diagnosis. However, recent data-driven sub-phenotyping has unveiled high-risk clusters of individuals with increased T2D risk, that differ profoundly in body fat distribution, insulin resistance […]

Introduction and Objective: Early vascular aging (EVA), based on vascular age gap (VAG), reflects excess vascular aging beyond chronological age, but its clinical relevance in type 1 diabetes (T1D) remains unclear. We aimed to characterize EVA based on carotid intima-media thickness (cIMT) and its associations with microvascular complications in adults with T1D.Methods: This cross-sectional study […]