Category: Diabetes

In the last two decades, significant progress has been made toward understanding the genetic basis of type 2 diabetes. An important supporter of this research has been the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), most recently through the Accelerating Medicines Partnership Program for Type 2 Diabetes (AMP T2D) and Accelerating Medicines […]

National Research Foundation of Korea (NRF)NRF-2020R1A3B2078617RS-2023-00218616RS-2024-00460865 Source link

The study by Kohda et al. (1) in this issue of Diabetes is a remarkable contribution to the field of adipose tissue biology and metabolic research. The authors have used cutting-edge single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to dissect the intricate cellular interactions within adipose tissue during obesity-induced fibrosis. Their identification of novel cell-to-cell communications […]

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Growing up, Carmella Evans-Molina felt there were limited options for a girl in West Virginia coal country. She grew up in the shadow of Kopperston Mountain, living, until age 4, in a row house in an old coal camp—“rows and rows of houses that all looked the same,” she says—the vestige of a company town. […]

In this special episode on Fish Oil –  Facts, Fiction, and EPA our host, Dr. Neil Skolnik, will discuss the evidence distinguishing fish oil from EPA (Icosapent ethyl).  This special episode is supported by an independent educational grant from Amarin. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, […]

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]

Small glycemic increments (≤0.5 mmol/L) can exert suppressive actions on endogenous glucose production (EGP); however, it is unclear if this is an insulin-dependent or -independent process. Here, we performed a low-rate glucose infusion in control participants without diabetes and in people with type 1 diabetes (T1D) to better understand this phenomenon. Glucose kinetics, hormones, and […]

High-affinity islet autoantibodies predict type 1 diabetes in mice and humans and implicate germinal centers (GCs) in disease pathogenesis. T follicular helper (Tfh) cells are increased in individuals with type 1 diabetes and alterations in Tfh-like cells in the peripheral blood predicted individual responses to abatacept. Tfh cells support GC responses and depend on the […]

Type 1 diabetes (T1D) is an autoimmune disease mediated by autoreactive T cells. Our studies indicate that CD4 T cells reactive to hybrid insulin peptides (HIPs) play a critical role in T-cell–mediated β-cell destruction. We have shown that HIPs form in human islets between fragments of the C-peptide and cleavage products of secretory granule proteins. […]