Category: Diabetes

Introduction and Objective: Diabetic foot ulcers (DFUs) remain a major complication of diabetes associated with impaired healing and amputation risk. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment, but evidence continues to evolve. The objective of this updated systematic review and meta-analysis is to analyze the efficacy of hyperbaric oxygen for the […]

Introduction and Objective: Accurate risk stratification in Diabetic Kidney Disease (DKD) is often confounded by nephroprotective medications (e.g., SGLT2i) and the non-linear dynamics of traditional biomarkers in advanced stages. This study evaluated the disease specificity and independent prognostic value of a novel biomarker, uPTM-FetA/Ucr, across the diabetes disease continuum, in a real-world cohort.Methods: A cross-sectional […]

Introduction and Objective: Treatment discontinuation in painful diabetic peripheral neuropathy (PDPN) is common and may result in periods without active therapy. We used a decision tree model to evaluate how discontinuation patterns influence risk of diabetic foot ulcer (DFU), amputation, and costs.Methods: A decision tree simulated 1,000 adults initiating PDPN therapies modeling periods without treatment. […]

Introduction and Objective: Diabetes and chronic respiratory diseases (RD) frequently coexist and share inflammatory features. However, whether metabolic dysfunction similarly influences inflammatory and vascular profiles across these conditions is unclear.Methods: We investigated shared and disease-specific metabolic inflammatory patterns in diabetes, RD, and their coexistence. We analyzed 262 subjects after excluding major confounders. Participants were classified […]

Introduction and Objective: PA is often required for diabetes medications and technologies, but its impact on PwD is not well characterized. This study examined the perspectives of PwD regarding the PA process in diabetes care.Methods: A cross-sectional, anonymous survey was conducted among PwD aged ≥18 years or caregivers of children with diabetes in the U.S. […]

Introduction and Objective: High HbA1c is linked to lower aerobic exercise capacity (VO2peak), even when exercise-training levels are matched, suggesting hyperglycemia may alter the adaptive response to exercise. Each acute bout of exercise induces changes in circulating proteins that mediate exercise response. We determined how T1D alters circulating proteins at rest and with exercise and […]

Introduction and Objective: The Alliance of Community Health Plans (ACHP) is a nonprofit trade association representing nonprofit community health plans. To advance its Chronic Disease Pledge to improve diabetes outcomes by 2030, ACHP members worked together with the International Diabetes Center to understand payer policies related to continuous glucose monitoring (CGM). This project, supported by […]

Introduction and Objective: Emerging evidence suggests that glycemic variability may influence outcomes in sepsis. Our objective was to investigate the correlation between acute glycemic variability and mortality as well as other clinical outcomes in sepsis.Methods: Patients aged 18 years or older with sepsis were enrolled in this prospective observational study during 2024-2025. Capillary blood glucose […]

Introduction and Objective: Teplizumab (TPZ), an anti-CD3 monoclonal antibody, is approved in the US to delay stage 3 T1D onset in individuals aged ≥8 years (y) with stage 2 T1D. We present screening and real-world treatment (Tx) patterns from individuals in the US who received TPZ according to their age group.Methods: TEPLI-REAL (NCT06892002) was a […]

Introduction and Objective: Insulin-like growth factor-1 receptor (IGF-1R) inhibitor has been developed as an effective therapy for thyroid eye disease (TED). However, treatment-associated hyperglycemia remains a clinical concern. We aimed to examine whether early glycemic deterioration during IGF-1R inhibitor therapy is associated with subsequent glycemic trajectories and to develop and validate a risk prediction model.Methods: […]