Category: Diabetes

Introduction and Objective: Incretin-based therapies have emerged as effective interventions for weight management. While small-molecule glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as Orforglipron, demonstrate meaningful clinical efficacy, evidence from MariTide indicates that simultaneously agonizing GLP-1R and antagonizing glucose-dependent insulinotropic polypeptide receptor (GIPR) pathways can provide more robust outcomes than targeting GLP-1R alone. Here we report […]

Introduction and Objective: CGM is increasingly used among adults with T2D, including non-insulin-treated patients in primary care. It may enable more timely assessment and care quality control during ongoing digital health interventions. This study evaluated weekly changes in CGM-derived glycemic metrics and compared HbA1c outcomes with BGM users in a digital health program.Methods: Data from […]

Introduction and Objective: GZR102 injection (GZR102) is a novel once-weekly fixed-ratio combination (FRC) of insulin GZR4 and the GLP-1 analog bofanglutide (GZR18). GZR102 is designed to preserve the pharmacokinetic (PK) characteristics of the individual components while delivering complementary glycemic control and metabolic benefits in people with T2DM.Methods: Potential drug-drug interactions (DDI) were assessed. PK profiles […]

Introduction and Objective: Type 2 diabetes frequently presents with comorbidities including hypertension, obesity, hypertriglyceridemia, thyroid disorders, myocardial infarction, and chronic kidney disease. Hypertriglyceridemia is linked to insulin resistance and elevated blood glucose. This study evaluated the safety and efficacy of saroglitazar, a dual PPAR-α/γ agonist, in Indian adults with type 2 diabetes and comorbidities.Methods: This […]

Introduction and Objective: TLC-1180 (1180) is a liver-targeted mitochondrial protonophore in clinical development. Insulin resistance is a major factor in the pathogenesis of T2D and metabolic alterations associated with insulin resistance are linked to heart failure with preserved ejection fraction (HFpEF). This study aims to evaluate the effects of 1180 on tissue specific insulin resistance […]

Introduction and Objective: This study investigated the glucodynamics and hypoglycemia risk associated with exercise or fasting during once-weekly basal insulin icodec treatment.Methods: Thirty basal insulin-treated, physically active individuals with T2D were enrolled. Icodec was dosed for ≥7 wks to target FPG of 80-130 mg/dL. When icodec steady state was achieved, 40 min cycling (EXE; 60% […]

Introduction and Objective: FCL transcends reducing the burden of carbohydrate counting. FCL eliminates the need for meal management by the person with diabetes and restores the normal manner in which people without diabetes interact with food. That is a true freedom that people with diabetes have never known. A novel MiniMed™ FCL algorithm featuring personalized […]

Introduction and Objective: Pakistan has the highest diabetes prevalence globally, with more than 34.5 million affected individuals—a figure projected to reach 62 million by 2045. 1,2 Currently, 1 in 4 adults has diabetes. Over 24 million adults with diabetes are not receiving treatment, meaning 67% of diabetics in the country are untreated. 4Objectives:Awareness campaigns to […]

Introduction and Objective: There is a decades old perception that women of African descent prefer large body sizes. Even though body size preference is a major determinant of health behavior, the 21st century view of body size preference in African immigrant (Afr-Im) and African American (AA) women is unknown. Our goal was to assess and […]

Introduction and Objective: Pancreatogenic diabetes (T3cDM) results from pancreatic exocrine dysfunction leading to endocrine insufficiency. Although linked to acute/chronic pancreatitis (AP/CP) and pancreatic cancer (PC), the incidence and predictors of diabetes after these conditions require clarification. This study determines the pooled incidence of new-onset diabetes following AP, CP, and PC and identifies disease-specific risk factors.Methods: […]