Category: Diabetes

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Establishing the relevance of a genetic variant in the causality of a given disease is crucial. Clinical molecular geneticists use a variety of tools including mode of inheritance, segregation in the family, penetrance, and determination of the variant as loss of function (LOF) or gain of function (GOF). However, this approach to determining how a […]

It has never been a bigger problem than now: it is estimated that more than 800 million people have chronic kidney disease (CKD) and diabetes is the leading cause of CKD, all projections say that prevalence of both type 2 diabetes and CKD will increase in the coming years, and CKD is expected to become […]

A key question for scientists as they raced to understand SARS-CoV-2: what was the human entry point for the virus that causes COVID-19? The answer, angiotensin-converting enzyme 2 (ACE2), was a protein Susan Gurley had studied for decades, not as a virologist but as a nephrologist. “I still study ACE2 in the context of kidney […]

By stimulating hepatic glucose production, glucagon (released by islet α-cells) restores normal blood glucose levels when they fall below the normal range. We used optogenetics in conjunction with electrophysiology, cytoplasmic free Ca2+ concentration imaging, and hormone release measurements to explore the intrinsic and paracrine regulation of glucagon secretion. Many α-cells were spontaneously active at 1 […]

The primary treatment for obesity involves calorie restriction (CR) to promote dietary weight loss achieved through interventions including behavioral modification, bariatric surgery, and antiobesity medications. In adults with obesity, CR-induced weight loss enhances physical function and improves quality of life, while also reducing the burden of various obesity-related chronic conditions, including hypertension, diabetes, obstructive sleep […]