Category: Diabetes

Introduction and Objective: Excessive diabetes device alerts can be burdensome for people with diabetes. Frequent autocorrection boluses inherent to the MiniMed™ 780G (MM780G) system are shown to reduce nighttime (SG) alarms/alerts.1 The present study assessed SG alarm/alert burden and glycemia in system users with and without optional SG alerts on.Methods: Deidentified CareLink™ data (01FEB2025 to […]

Introduction and Objective: Skeletal muscle plays a central role in whole-body lipid metabolism through mitochondrial and peroxisomal fatty acid oxidation (FAO). When skeletal muscle lipid metabolism is impaired, whole-body adaptations occur to maintain metabolic homeostasis. We hypothesized that limiting skeletal muscle lipid metabolism through mitochondria &/or peroxisomes would trigger adaptive responses to reduce dietary lipid […]

Introduction and Objective: RNA modifications are crucial regulators of gene expression in human development. They have an established role in regulating β cell development and function, with dysregulation resulting in diabetes. Numerous limitations have restricted the study of these modifications directly in pancreatic tissue. We utilize a cohort of human fetal pancreatic samples to determine […]

Introduction and Objective: Despite its systemic impact, MASLD is often overlooked in routine T2DM care. Our study evaluates whether glycemic status and the NFS are associated with the prevalence and severity of microvascular complications in hospitalized patients with T2DM.Methods: Our retrospective cross-sectional study analyzed data from 4,009 hospitalized patients with T2DM in Almaty, Kazakhstan (2017-2019). […]

Introduction and Objective: Recurrent insulin-induced hypoglycemia blunts the counterregulatory response (CRR) to hypoglycemia. Since antecedent hyperinsulinemia coincides with antecedent hypoglycemia, it is possible that recurrent insulin administration per se could contribute to the pathophysiology of a blunted CRR. To target insulin delivery to the central nervous system, this study tested the hypothesis that recurrent intranasal […]

Introduction and Objective: Physical activity (PA) is important in type 1 diabetes (T1D) management. However, PA poses challenges as it can cause unpredictable changes in blood glucose (BG) levels. Key reasons include insulin-glucose mismatch, nutrition, type of activity, and individual variability. The Clinical Sports and Activity Program (CSAP) at the Wendy Novak Diabetes Institute educates […]

Introduction and Objective: Type 1 diabetes (T1D) increases the risk of depression. Pregnancy can be a particularly stressful time for women with T1D, but little is known about pregnancy-related psychosocial health in this population. We report on the prevalence of depressive symptoms and diabetes distress measured by validated surveys among pregnant and postpartum women participating […]

Introduction and Objective: β-cell secretory reserve declines prior to overt hyperglycemia but there are no direct clinical biomarkers. We asked whether shorter RT of insulin (Ins) or C-peptide (C-P) in β-cells before secretion non-invasively reveals reversibility of β-cell dysfunction in HFD-fed fZDF treated with rosiglitazone (Rosi).Methods: fZDF were on HFD or chow for 10, 20, […]

Introduction and Objective: Accurate control population-based thresholds for Islet autoantibodies positivity are essential to diagnosed and predict type 1 diabetes (T1D). Most positivity thresholds come from European populations, and it remains unclear whether these thresholds differ across ancestries within the same country.Methods: We analyzed GADA, IA-2A and ZnT8A in 1543 diabetes-free adults (595 -European, 474 […]

Introduction and Objective: Recent evidence suggests that extra-pancreatic tissues, including the stomach, may also express insulin. The aim of this study was to investigate whether the human stomach expresses insulin and key β-cell-associated transcriptional markers, and to characterize the cellular and spatial context of such expression.Methods: Gastric biopsies were obtained from 15 human subjects undergoing […]