1508-P: Knowledge of Alzheimer’s Disease and Related Dementia and Associated Factors among Middle-Aged and Older Adults with Type 2 Diabetes

by sugaradmin



Introduction and Objective: Individuals with type 2 diabetes (T2D) are 1.5-2 times more likely to develop Alzheimer’s disease and related dementias (ADRD) than those without. Despite evidence that midlife cardiovascular risk factors increase later-life cognitive decline, limited data exist on ADRD knowledge and misconceptions among middle-aged adults with T2D. Guided by the Science of Behavioral Change framework, we examined ADRD knowledge and associated social and self-regulatory factors among adults with T2D (≥40 years).Methods: This cross-sectional study recruited participants via ResearchMatch and local organizations in Arizona. Data included sociodemographic and clinical characteristics, perceived risk, and validated measures of ADRD knowledge, social support/isolation, self-efficacy, engagement in brain health-promoting behaviors, and resilience. Multivariable logistic regression identified associated factors.Results: Among 102 participants (mean age 58±11 years), 67% were female, 77% non-Hispanic White, and 63% had a college degree or higher. The mean knowledge score was 10±4 (range 1-17), with 44% demonstrating adequate knowledge (≥70% correct score). After adjustment, greater social support (OR=1.06, p=0.040), engagement in brain health-promoting behaviors (OR=1.17, p=0.017), and higher perceived risk (OR=35.56, p<0.001) were associated with higher odds of adequate knowledge. Social isolation (OR=0.07, p=0.019) and family history of dementia (OR=0.15, p=0.019) were associated with lower odds. Surprisingly, compared with no/high school education, some college (OR=0.01, p=0.003), college (OR=0.02, p=0.008), and graduate education (OR=0.00, p=0.001) were associated with lower odds. No association with self-efficacy was observed.Conclusion: Adults with T2D demonstrated limited knowledge of ADRD. Socially informed interventions are needed to improve understanding of ADRD and brain health literacy.

Disclosure

E.O. Owolabi: None. M. Boakye: None. R. Seltzer: None. F. Yu: None.

Funding

Arizona State University Discovery Pilot Fund



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