Share on PinterestRock legend Ozzy Osbourne shared the health challenges he faced living with Parkinson’s disease in the years before his death at 76. Harry How/Getty Images The effects of Parkinson’s disease are back in the spotlight after the death of singer Ozzy Osbourne. Experts say Parkinson’s can cause a wide variety of health issues, […]
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Discussion This study represents the first and largest direct comparison of GLP-1 RAs and metformin in mitigating dementia risk among patients with T2DM. Historically, metformin has been the cornerstone of first-line therapy for T2DM due to its well-established efficacy in glycemic control and its potential neuroprotective effects.20–28 However, whether initiating GLP-1 RAs as first-line therapy […]
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Share on PinterestDespite the popularity of trendy alkaline or electrolyte-infused waters, regular tap water can also help you stay sufficiently hydrated. Ekaterina Goncharova/Getty Images Proper hydration is essential for health, especially during the hot summer months. Alkaline or electrolyte-infused waters are often touted for their purported health benefits, but experts say tap water is cheaper […]
Read MoreGlucokinase (GK) activators (GKAs) are a long-sought therapeutic modality for the treatment of type 2 diabetes. However, GKAs have failed in clinical trials, with the recent exception of dorzagliatin (Hua Medicine). A comprehensive approach using human islet perifusions, enzyme kinetics, X-ray crystallography, and modeling studies was applied to compare the effects of dorzagliatin with those […]
Read MoreIndividuals with type 1 diabetes (T1D) or permanent neonatal diabetes (PND) due to an INS gene mutation (INS-PND) have a marked reduction in pancreas volume by MRI compared with control individuals with no diabetes (ND). One possible explanation for this is loss of islet-acinar insulin signaling in these forms of severe insulin deficiency. To test […]
Read MoreDiabetic peripheral neuropathy (DPN) poses significant clinical challenges due to progressive nerve degeneration and vascular insufficiency. To address both neural and vascular complications simultaneously, we employed an mRNA-based protein replacement therapy. In this study, leveraging mRNA template design, structure-based screening identified NGFR100W as a variant dissociating neuroprotective and nociceptive functions, demonstrating enhanced neuritogenic activity without […]
Read MoreThe impact of atmospheric pressure changes on glucose metabolism encountered in aviation on people with type 1 diabetes is controversial. A dual-isotope study was performed in a hypobaric chamber to simulate pressure changes experienced on commercial flights. The fasting and postprandial glucose kinetics of individuals with type 1 diabetes were evaluated across simulated in-flight cabin […]
Read MoreGastrointestinal hormones are essential for nutrient handling and regulation of glucose metabolism and may affect postprandial blood redistribution. In a randomized cross-over design in 10 healthy men, the involvement of glucose-dependent insulinotropic polypeptide (GIP) in splanchnic blood flow regulation was investigated using an infusion of GIP receptor antagonist (GIPR-An) GIP(3-30)NH2 during ingestion of oral glucose […]
Read MoreCirculating glucagon concentrations differ between individuals with no diabetes (ND) and those with type 1 diabetes (T1D). We combined an isotope dilution technique using stable tracers [6,22-13C9,15N1]glucagon and [6,14,19,22-13C9,15N1]glucagon with splanchnic and leg catheterization in participants with ND (n = 8; age 23.1 ± 2.9 years, BMI 26.6 ± 3.5 kg/m2, HbA1c 5.0 ± 0.2% […]
Read MoreIntraportal islet transplantation to treat insulin-dependent diabetes has been clinically validated. However, the hypoxic environment and sinusoidal architecture of the liver are unsuitable for the long-term survival of transplanted islets, leading to the loss of therapeutic effects within 1 year. The spleen has oxygen levels that meet islet needs, but intense instant blood-mediated inflammatory reactions […]
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