Author: sugaradmin

White adipose tissue (WAT) insulin resistance (IR) is a central feature of metabolic syndrome; however, data regarding defects in WAT insulin signaling in humans with IR is limited. To determine which defects in WAT insulin signaling are associated with human IR, WAT was obtained from three cohorts of patients with obesity. In a bariatric surgery […]

Type 2 diabetes and obesity are commonly accompanied by metabolic dysfunction–associated steatotic liver disease (MASLD), increasing the risk of developing metabolic dysfunction–associated steatohepatitis (MASH) and fibrosis. The early stages of MASLD are characterized by dysfunctional lipid metabolism, including remodeling of the hepatic lipidome. In this context, reductions in hepatic phosphatidylserine (PS) have been associated with […]

Insulin secretion varies widely in preclinical type 1 diabetes. To understand the pathogenesis of this metabolic heterogeneity, we asked whether genetic predisposition to type 2 diabetes, quantified by a type 2 diabetes genetic risk score (T2D-GRS), modulates β-cell function and disease progression in individuals at risk of type 1 diabetes. We analyzed 4,324 islet autoantibody–positive […]

The study by Keller et al. (1) demonstrated that urinary Dickkopf-3 (uDKK3) independently predicted kidney function decline and mortality among individuals with type 2 diabetes managed in primary care. However, a reassessment of their data reveals two clinically important yet underexplored patterns and several potential methodological limitations that may influence both interpretation and applicability. Source link

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For a career in diabetes, Jay Sosenko was in the right place at the right time. He had just started a fellowship in adolescent medicine at the Children’s Hospital Medical Center in Boston when he heard about a new breakthrough making waves in medicine. The attending physician in the adolescent diabetes clinic, Dr. Kenneth Gabbay, […]