Share on PinterestHeavy menstrual bleeding is common during perimenopause and can lead to iron deficiency anemia, a well-known cause of fatigue. Maskot/Getty Images A recent study found that abnormal menstrual bleeding during perimenopause is associated with fatigue. If left untreated, heavy menstrual bleeding can lead to iron deficiency anemia, a well-known cause of fatigue. Females […]
Read MoreDiabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]
Read MoreDiabetic neuropathic pain is associated with elevated plasma levels of methylglyoxal (MGO). MGO is a metabolite of glycolysis that causes pain hypersensitivity in mice by stimulating the phosphorylation of eukaryotic initiation factor 2α (p-eIF2α) and subsequently activating the integrated stress response (ISR). We first established that Zucker diabetic fatty rats have enhanced MGO signaling, engage […]
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Discussion This cross-sectional study indicates that women aged 18–45 years diagnosed with type 2 diabetes in South London are exposed to several factors that increase their pregnancy risk profile. With only 1 in 10 women in this cohort prescribed contraception by their GP, the risk of an unplanned pregnancy was high, even allowing for the […]
Read MoreWelcome to this special edition of Diabetes Core Update, where host Dr. Neil Skolnik takes a deep dive into the transformative role of continuous glucose monitoring (CGM) in diabetes care. Through engaging conversations with two leading experts, Dr. Skolnik explores the latest advancements in CGM technology, its clinical benefits, and its growing accessibility. Packed with […]
Read MoreObesity in childhood is associated with adulthood obesity, type 2 diabetes (T2D), and future metabolic complications. The gut microbiota is a modifier of host metabolic function with altered bacterial composition associated with disease risk. Few studies have investigated the relationships among metabolic disease, inflammation, and the gut microbiota in youth, in whom these connections likely […]
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Results CD8(+) T cells, primarily with a central memory phenotype, are a major component of the lymphoid immune cell population in islets, with no significant differences between type 2 diabetic and non-diabetic donors. We initially analyzed the lymphoid composition of human pancreatic islets using multicolor flow cytometry on CD45(+) T cells from dispersed islets of […]
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Share on PinterestTwo new studies highlight the potential risks to heart health among young adults who use cannabis. Olena Bondarenko/Getty Images A retrospective study found that cannabis users were six times as likely to have a heart attack compared to non-users. A meta-analysis of 12 previous studies showed that cannabis users had a 50% higher […]
Read MoreThis is the second episode in a special three-part series of the Diabetes Core Update podcast, focusing on heart failure with preserved ejection fraction (HFpEF) in people with diabetes. Sponsored by Roche, this series provides primary care clinicians and healthcare professionals with actionable insights into screening, diagnosis, and treatment of HFpEF, a major complication in […]
Read MoreThe association between KCNJ5 mutations and the risk of developing new-onset diabetes (NOD) in patients with unilateral primary aldosteronism (uPA) remains underexplored. To investigate this association, we conducted a longitudinal study using data from the Taiwan Primary Aldosteronism Investigation database. Our sample included 360 patients with uPA who underwent adrenalectomy between 2012 and 2017, 191 […]
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